Infiltrating Treg and Th17 Cells of the Prostate Hypertrophy Gland Associated with Propionibacterium Acnes Infection

Sebastian Radej; Paweł Płaza; Alina Olender; Monika Szewc; Krzysztof Bar; Ryszard Maciejewski

doi:10.2147/RRU.S284066

Infiltrating Treg and Th17 Cells of the Prostate Hypertrophy Gland Associated with Propionibacterium Acnes Infection

Res Rep Urol. 2020 Nov 30:12:593-597. doi: 10.2147/RRU.S284066. eCollection 2020.

Authors

Sebastian Radej¹, Paweł Płaza², Alina Olender³, Monika Szewc¹, Krzysztof Bar², Ryszard Maciejewski¹

Affiliations

¹ Department of Normal Anatomy, Medical University of Lublin, Lublin, Poland.
² Urology and Urological Oncology, Medical University of Lublin, Lublin, Poland.
³ Chair and Department of Medical Microbiology, Medical University of Lublin, Lublin, Poland.

Abstract

Purpose: The aim of the study was to evaluate prostate cell infiltration by CD4(+)IL-17(+) and Treg cells in BPH and PCa patients depending on P. acnes infection in the prostate gland.

Patients and methods: Prostate fragments were collected from 54 patients with PCa and 34 patients with BPH. Rapid ID 32 was used to identify the bacteria. Cells were analyzed by flow cytometry BD FACSCanto II. Statistical analysis was performed using Statistica 7 software (TIBCO Software Inc, USA).

Results: P. acnes was detected in 35% of patients with PCa and 41% of individuals with BPH. The infiltration of CD4(+)IL-17(+) and Treg cells was statistically significantly higher (P = 0.001) in patients with BPH and positive for P. acnes. A statistically considerably higher (P = 0.001) infiltration of Treg cells in treated for PCa with P.acnes infection was also demonstrated.

Conclusion: Prostatitis caused by P. acnes may contribute to the development of BPH and PCa.

Keywords: P. acnes; Th17 cells; Treg cells; benign prostatic hyperplasia; prostate cancer.