High-throughput approach for the in situ generation of magnetic ionic liquids in parallel-dispersive droplet extraction of organic micropollutants in aqueous environmental samples

Camila Will; Ricardo Dagnoni Huelsmann; Gabriela Mafra; Josias Merib; Jared L Anderson; Eduardo Carasek

doi:10.1016/j.talanta.2020.121759

High-throughput approach for the in situ generation of magnetic ionic liquids in parallel-dispersive droplet extraction of organic micropollutants in aqueous environmental samples

Talanta. 2021 Feb 1;223(Pt 2):121759. doi: 10.1016/j.talanta.2020.121759. Epub 2020 Oct 15.

Authors

Camila Will¹, Ricardo Dagnoni Huelsmann¹, Gabriela Mafra¹, Josias Merib², Jared L Anderson³, Eduardo Carasek⁴

Affiliations

¹ Departamento de Química, Universidade Federal de Santa Catarina, Florianópolis, SC, 88040-900, Brazil.
² Departamento de Farmacociências, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS, 90050-170, Brazil. Electronic address: josias@ufcspa.edu.br.
³ Department of Chemistry, Iowa State University, Ames, IA, 50011, USA.
⁴ Departamento de Química, Universidade Federal de Santa Catarina, Florianópolis, SC, 88040-900, Brazil. Electronic address: eduardo.carasek@ufsc.br.

PMID: 33298275
DOI: 10.1016/j.talanta.2020.121759

Abstract

In this work, a novel and high-throughput parallel-dispersive droplet extraction (Pa-DDE) based on in situ formation of the hydrophobic MILs ([Co(C₄IM)₄⁺²]2[NTf₂^-], [Ni(C₄IM)₄⁺²]2[NTf₂^-] and [Ni(BeIM)₄⁺²]2[NTf₂^-]) is demonstrated, for the first time, for the determination of benzophenone, metolachlor, triclocarban, pendimethalin, 4-methylbenzylidene camphor, and 2-ethylhexyl-4-methoxycinnamate from aqueous environmental samples. This experimental setup is comprised of a 96-well plate system containing a set of magnetic pins which were used to collect the MIL droplet after in situ formation. This consolidated system enabled simultaneous extraction of up to 96 samples and MIL production in one step. Using this apparatus, sample preparation times of 0.78 min per sample was achieved. The experimental conditions were carefully optimized using uni and multivariate approaches. The optimal conditions were comprised of sample volume of 1.25 mL, 4 mg of [Co(C₄IM)₄⁺²]2[Cl^-] and 40 μL of LiNTf₂ for the in situ formation, and dilution in 20 μL of acetonitrile. The analytical parameters of merit were successfully determined with LODs ranging from 7.5 to 25 μg L^-1 and coefficients of determination higher than 0.989. Intraday and interday precision ranged from 6.4 to 20.6% (n = 3) and 11.6-22.9% (n = 9), respectively, with analyte relative recovery ranging between 53.9 and 129.1%.

Keywords: 96-Well plate; In situ formation; Magnetic ionic liquids; Parallel dispersive droplet extraction; Sample preparation.