Is prophylactic central neck dissection justified in patients with cN0 differentiated thyroid carcinoma? An overview of the most recent literature and latest guidelines

Ann Ital Chir. 2020:91:451-457.

Abstract

To date, in patients with differentiated thyroid cancer, central neck dissection is recommended in the presence of central compartment lymph node metastases. Differently, the efficacy of prophylactic central neck dissection in case of clinically node-negative differentiated thyroid carcinoma remains still uncertain. There are many arguments in favor and many against the execution of this surgical procedure. The most recent literature and latest guidelines have been reviewed and illustrated, paying particular attention to currently hottest and most discussed points. Prophylactic central neck dissection is associated with higher rates of postoperative complications, such as recurrent laryngeal nerve injury and hypoparathyroidism, with unclear oncological benefits. Thus, in the absence of lymph node involvement, this procedure should be avoided, reserving it for high-risk patients with advanced primary tumors. Moreover, to avoid serious complications, prophylactic central neck dissection should be performed by high-volume surgeons. KEY WORDS: Clinically node-negative differentiated thyroid cancer, Differentiated thyroid carcinoma, Prophylactic central neck dissection.

Attualmente, nei pazienti con carcinoma tiroideo differenziato, la linfectomia del comparto centrale del collo è raccomandata in presenza di metastasi linfonodali in tale sede. L’efficacia della linfectomia profilattica del comparto centrale nel carcinoma tiroideo differenziato con linfonodi clinicamente negativi rimane invece ancora controversa. Esistono diversi argomenti a favore e diversi contro l’esecuzione di questa procedura chirurgica. Sono state revisionate ed illustrate la letteratura più recente e le ultime linee guida, prestando particolare attenzione ai punti più caldi e discussi. La linfectomia profilattica del comparto centrale è associata a tassi più elevati di complicanze postoperatorie, come lesioni del nervo laringeo ricorrente ed ipoparatiroidismo, con benefici oncologici poco chiari. Pertanto, in assenza di coinvolgimento linfonodale, tale procedura dovrebbe essere evitata, riservandola a pazienti ad alto rischio con tumori primari avanzati. Inoltre, per evitare gravi complicanze postoperatorie, questa la linfectomia profilattica del comparto centrale dovrebbe essere eseguita da chirurghi ad alto volume.

Publication types

  • Review

MeSH terms

  • Humans
  • Lymph Nodes
  • Lymphatic Metastasis
  • Neck Dissection*
  • Neoplasm Recurrence, Local
  • Practice Guidelines as Topic
  • Thyroid Neoplasms* / surgery
  • Thyroidectomy