Supplemental dataset on the influence of cardiac resynchronisation therapy in pacing-induced cardiomyopathy and concomitant central sleep Apnea

Fabian Barbieri; Agne Adukauskaite; Thomas Senoner; Andrea Rubatscher; Wilfried Schgör; Markus Stühlinger; Bernhard Erich Pfeifer; Axel Bauer; Florian Hintringer; Wolfgang Dichtl

doi:10.1016/j.dib.2020.106461

Supplemental dataset on the influence of cardiac resynchronisation therapy in pacing-induced cardiomyopathy and concomitant central sleep Apnea

Data Brief. 2020 Oct 28:33:106461. doi: 10.1016/j.dib.2020.106461. eCollection 2020 Dec.

Affiliations

¹ University Clinic of Internal Medicine III, Medical University Innsbruck, Innsbruck, Austria.
² Institute of Clinical Epidemiology, Tirol Kliniken, Innsbruck, Austria.
³ Institute of Medical Informatics, UMIT TIROL, Eduart Wallnöfer Zentrum, Hall in Tirol, Austria.

Abstract

This article contains supplemental data to the publication "Central Sleep Apnea and Pacing-Induced Cardiomyopathy" [1], which was the most recent publication of the "UPGRADE" study. It provides in-depth analysis of the effects of cardiac resynchronisation therapy (CRT) in patients suffering from pacing-induced cardiomyopathy (PICM) on cardiac remodeling as well as functional cardiac parameters in comparison to continuous right ventricular pacing (RVP). Furthermore, it also covers additional data on several sleep parameters, which were not presented in the main article including the index for obstructive sleep apnea (OSA), the index for mixed sleep apnea and the oxygen saturation measurements during polysomnography. Further, Kaplan-Meier curves are presented for major adverse cardiac events (MACE) and overall mortality by severity of sleep apnea. Generally, the "UGRADE" study was a single-center prospective double-blinded randomized controlled trial lasting from 2014 to 2020. The methodology included a cross-over design giving the possibility to detect differences while CRT was activated and while continuous RVP was applied. The presented data should aid clinicians in daily practice as upgrading to CRT is not limited to improvement in cardiac parameters, but also modifies sleep apnea in patients with PICM, a generally sparsely studied entity of heart failure.

Keywords: Cardiac remodeling; Cardiac resynchronisation therapy; Central sleep apnea; Pacing-induced cardiomyopathy; Sleep-disordered breathing.