Vitamin D supplementation and outcomes in coronavirus disease 2019 (COVID-19) patients from the outbreak area of Lombardy, Italy

Nutrition. 2021 Feb:82:111055. doi: 10.1016/j.nut.2020.111055. Epub 2020 Nov 11.

Abstract

  1. •

    Vitamin D has antiinflammatory and immunoregulatory functions.

  2. •

    The involvement of vitamin D in the pathophysiology of coronavirus disease 2019 (COVID-19) is still not clear.

  3. •

    Some studies support a link between vitamin D deficiency and worse COVID-19 outcomes.

  4. •

    Vitamin D may also enhance macrophage activation and aberrant immune response.

  5. •

    In our study, vitamin D supplementation was associated with a trend toward higher mortality.

  6. •

    Supplementation trials are crucial to clarify the role of vitamin D in COVID-19.

Keywords: COVID-19; Coronavirus (SARS-CoV-2); Hospitalization; Mortality; Outcome; Vitamin D.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • COVID-19 / blood
  • COVID-19 / mortality*
  • COVID-19 / therapy*
  • COVID-19 Drug Treatment*
  • Dietary Supplements*
  • Disease Outbreaks
  • Female
  • Humans
  • Italy
  • Male
  • Middle Aged
  • Nutritional Status
  • Prognosis
  • Prospective Studies
  • SARS-CoV-2
  • Treatment Outcome
  • Vitamin D / analogs & derivatives
  • Vitamin D / blood
  • Vitamin D / therapeutic use*
  • Vitamin D Deficiency / blood
  • Vitamin D Deficiency / mortality
  • Vitamin D Deficiency / virology

Substances

  • Vitamin D
  • 25-hydroxyvitamin D