Enhancer of zeste homolog 2(EZH2) is a histone methyltransferase which regulate gene expression through epigenetic machinery. The abnormal expression of EZH2 has been described in many cancer types. With in-depth study, it was found that EZH2 is involved in the occurrence and development in many kinds of malignant hematologic disease which may play a dual role of oncogenes and tumor suppressor genes. In recent years, the emergence of EZH2 inhibitors provide a new option for the future treatment of hematological malignancies. In this review, the expression and clinical significance of EZH2 in various of hematological tumors were summarized briefly.
题目: EZH2在恶性血液病中的表达及临床意义的研究进展.
摘要: EZH2是一种参与基因表观遗传调控的甲基转移酶，其在多种肿瘤中均存在异常表达。随着EZH2在血液系统恶性肿瘤中研究的不断深入，发现EZH2参与多种恶性血液病的发生发展，在血液系统恶性肿瘤中可能扮演着致癌及抑癌基因的双重角色。近年来，EZH2抑制剂的不断涌现为今后血液系统恶性肿瘤的治疗提供了一个新的选择。本文将对EZH2在各种血液系统肿瘤中的表达及临床意义的最新研究进展作一综述.