The cardiac complications of COVID-19: many publications, multiple uncertainties

Vasc Biol. 2020 Oct 20;2(1):R105-R114. doi: 10.1530/VB-20-0009. eCollection 2020.

Abstract

Since the first description of COVID-19 in December 2019, more than 63,000 publications have described its virology, clinical course, management, treatment and prevention. Most physicians are now encountering, or will soon encounter, patients with COVID-19 and must attempt to simultaneously assimilate this avalanche of information while managing an entirely novel disease with few guiding precedents. It is increasingly clear that, although primarily a respiratory illness, COVID-19 is associated with cardiovascular complications. However, the true incidence of direct cardiac complications remains unclear, as all complications thus far reported can also occur in patients without COVID-19. In this review, we briefly summarise and critically appraise the data on cardiac complications associated with COVID-19 and describe some cases from our own experience. We identify unresolved questions and highlight the many uncertainties in this developing field.

Keywords: COVID-19; infection; inflammation; microvasculature; myocardial injury; thrombosis; vascular disease.

Publication types

  • Review