Repetitive optical coherence elastography measurements with blinking nanobombs

Paul Boerner; Dmitry Nevozhay; Maryam Hatamimoslehabadi; Harshdeep Singh Chawla; Fernando Zvietcovich; Salavat Aglyamov; Kirill V Larin; Konstantin V Sokolov

doi:10.1364/BOE.401734

Repetitive optical coherence elastography measurements with blinking nanobombs

Biomed Opt Express. 2020 Oct 22;11(11):6659-6673. doi: 10.1364/BOE.401734. eCollection 2020 Nov 1.

Authors

Paul Boerner^{1

2}, Dmitry Nevozhay^{3

2}, Maryam Hatamimoslehabadi¹, Harshdeep Singh Chawla¹, Fernando Zvietcovich¹, Salavat Aglyamov⁴, Kirill V Larin^{1

5}, Konstantin V Sokolov^{3

6

7

8}

Affiliations

¹ Department of Biomedical Engineering, University of Houston, Houston, Texas 77204, USA.
² Equal contribution.
³ Department of Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
⁴ Department of Mechanical Engineering, University of Houston, Houston, Texas 77204, USA.
⁵ klarin@uh.edu.
⁶ Department of Bioengineering, Rice University, Houston, Texas 77030, USA.
⁷ Department of Biomedical Engineering, The University of Texas at Austin, 107 W Dean Keeton Street, Austin, Texas 78712, USA.
⁸ ksokolov@mdanderson.org.

Abstract

Excitation of dye-loaded perfluorocarbon nanoparticles (nanobombs) can generate highly localized axially propagating longitudinal shear waves (LSW) that can be used to quantify tissue mechanical properties without transversal scanning of the imaging beam. In this study, we used repetitive excitations of dodecafluoropentane (C5) and tetradecafluorohexane (C6) nanobombs by a nanosecond-pulsed laser to produce multiple LSWs from a single spot in a phantom. A 1.5 MHz Fourier-domain mode-locked laser in combination with a phase correction algorithm was used to perform elastography. Multiple nanobomb activations were also monitored by detecting photoacoustic signals. Our results demonstrate that C6 nanobombs can be used for repetitive generation of LSW from a single spot for the purpose of material elasticity assessment. This study opens new avenues for continuous quantification of tissue mechanical properties using single delivery of the nanoparticles.

Abstract

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