Tryptoquivalines W and X, two new compounds from a Hawaiian fungal strain and their biological activities

Kh Ahammad Uz Zaman; Zhenquan Hu; Xiaohua Wu; Shugeng Cao

doi:10.1016/j.tetlet.2020.151730

Tryptoquivalines W and X, two new compounds from a Hawaiian fungal strain and their biological activities

Tetrahedron Lett. 2020 Apr 2;61(14):151730. doi: 10.1016/j.tetlet.2020.151730. Epub 2020 Feb 11.

Authors

Kh Ahammad Uz Zaman¹, Zhenquan Hu^{2

3}, Xiaohua Wu¹, Shugeng Cao^{1

4}

Affiliations

¹ Daniel K. Inouye College of Pharmacy, University of Hawaii at Hilo, 200 West Kawili Street, Hilo, HI 96720, United States.
² Warshel Institute for Computational Biology, The Chinese University of Hong Kong, Shenzhen, People's Republic of China.
³ School of Chemistry and Materials Science, University of Science and Technology of China, People's Republic of China.
⁴ Cancer Biology Program, University of Hawaii Cancer Center, 701 Ilalo Street, Honolulu, HI 96813, United States.

Abstract

Two new compounds tryptoquivalines W (1) and X (2) were isolated from a Hawaiian soil fungal strain Aspergillus terreus FS107. The soil sample was collected on the top of Mauna Kea, the tallest mountain in Hawaii. The structures of compounds 1 and 2 were determined on the basis of MS spectroscopic and NMR analysis, and NMR calculation. The absolute configuration (AC) was determined by ECD calculations. Compounds 4 and 5 showed inhibition against NF-κB with IC₅₀ values of 3.45 and 6.76 μM, respectively.

Keywords: Fungus; NF-κB; NMR; Tryptoquivaline.

Grants and funding

P20 GM103466/GM/NIGMS NIH HHS/United States