Mediastinal Cystic Parathyroid Adenoma Diagnosed by Somatostatin Receptor Scintigraphy

Intern Med. 2021 May 15;60(10):1555-1560. doi: 10.2169/internalmedicine.6381-20. Epub 2020 Dec 7.

Abstract

A 71-year-old man complained of nausea and loss of appetite for eight months prior to admission. He was transported to a hospital with disorientation and diagnosed with primary hyperparathyroidism by laboratory examinations. However, ultrasonography, computed tomography, and technetium-99m labeled methoxyisobutyl isonitrile (99mTc-MIBI) with single-photon emission computed tomography did not yield definite results. In contrast, somatostatin receptor scintigraphy successfully identified the lesion responsible for the over-secretion of parathyroid hormone within the middle mediastinum. The tumor was successfully resected by surgery, and a histopathological analysis confirmed the parathyroid adenoma nature of the tumor.

Keywords: 111In-pentetreotide scintigraphy; ectopic parathyroid adenoma; parathyroid hormone; primary hyperparathyroidism; somatostatin receptor scintigraphy.

Publication types

  • Case Reports

MeSH terms

  • Adenoma* / diagnostic imaging
  • Adenoma* / surgery
  • Aged
  • Humans
  • Male
  • Parathyroid Glands
  • Parathyroid Neoplasms* / diagnostic imaging
  • Parathyroid Neoplasms* / surgery
  • Radionuclide Imaging
  • Radiopharmaceuticals
  • Receptors, Somatostatin
  • Technetium Tc 99m Sestamibi
  • Tomography, Emission-Computed, Single-Photon

Substances

  • Radiopharmaceuticals
  • Receptors, Somatostatin
  • Technetium Tc 99m Sestamibi