Alcohol drinking and brain morphometry in apparently healthy community-dwelling Japanese men

Ali Haidar Syaifullah; Akihiko Shiino; Akira Fujiyoshi; Aya Kadota; Keiko Kondo; Takahiro Ito; Hiroyoshi Segawa; Mohammad Moniruzzaman; Takashi Waki; Naoko Miyagawa; Ikuo Tooyama; Hirotsugu Ueshima; Katsuyuki Miura; SESSA Research Group; Co-chairpersons; Hirotsugu Ueshima; Katsuyuki Miura; Research members

doi:10.1016/j.alcohol.2020.11.006

Alcohol drinking and brain morphometry in apparently healthy community-dwelling Japanese men

Alcohol. 2021 Feb:90:57-65. doi: 10.1016/j.alcohol.2020.11.006. Epub 2020 Dec 3.

Authors

Ali Haidar Syaifullah¹, Akihiko Shiino², Akira Fujiyoshi³, Aya Kadota⁴, Keiko Kondo⁵, Takahiro Ito⁵, Hiroyoshi Segawa⁶, Mohammad Moniruzzaman⁴, Takashi Waki⁷, Naoko Miyagawa⁸, Ikuo Tooyama⁹, Hirotsugu Ueshima⁴, Katsuyuki Miura⁴; SESSA Research Group; Co-chairpersons; Hirotsugu Ueshima¹⁰, Katsuyuki Miura¹⁰; Research members

Collaborators

Minoru Horie¹⁰, Yoshihisa Nakagawa¹⁰, Takashi Yamamoto¹⁰, Yasutaka Nakano¹⁰, Emiko Ogawa¹⁰, Hiroshi Maegawa¹⁰, Katsutaro Morino¹⁰, Itsuko Miyazawa¹⁰, Yoshiyuki Watanabe¹⁰, Kazuhiko Nozaki¹⁰, Ikuo Tooyama¹⁰, Akihiko Shiino¹⁰, Akira Andoh¹⁰, Teruhiko Tsuru¹⁰, Hisakazu Ogita¹⁰, Naomi Miyamatsu¹⁰, Yasuyuki Nakamura¹⁰, Aya Kadota¹⁰, Keiko Kondo¹⁰, Sayuki Torii¹⁰, Takashi Kadowaki¹⁰, Sayaka Kadowaki¹⁰, Sentaro Suzuki¹⁰, Takahiro Ito¹⁰, Ayako Kunimura¹⁰, Hiroyoshi Segawa¹⁰, Akira Fujiyoshi¹¹, Aya Higashiyama¹¹, Tomonori Okamura¹², Koichiro Azuma¹², Tatsuya Sawamura¹³, Michiya Igase¹⁴, Yasuharu Tabara¹⁵, Akira Sekikawa¹⁶, Emma J M Barinas-Mitchell¹⁶, Daniel Edmundowicz¹⁷, Takayoshi Ohkubo¹⁸, Atsushi Hozawa¹⁹, Yoshitaka Murakami²⁰, Nagako Okuda²¹, Hisatomi Arima²², Atsushi Satoh²², Yoshikuni Kita²³, Takashi Hisamatsu²⁴, Masahiko Yanagita²⁵, Robert D Abbott²⁶, Seiko Ohno²⁷, Naoyuki Takashima²⁸, Naoko Miyagawa²⁹, Maryam Zaid³⁰, Yoshino Saito³¹

Affiliations

¹ Biomedical MRI Science Center, Shiga University of Medical Science, Shiga, Japan; Center for the Epidemiologic Research in Asia (CERA), Shiga University of Medical Science, Shiga, Japan.
² Biomedical MRI Science Center, Shiga University of Medical Science, Shiga, Japan. Electronic address: shiino@belle.shiga-med.ac.jp.
³ Department of Hygiene, School of Medicine, Wakayama Medical University, Japan; Department of Public Health, Shiga University of Medical Science, Shiga, Japan.
⁴ Center for the Epidemiologic Research in Asia (CERA), Shiga University of Medical Science, Shiga, Japan; Department of Public Health, Shiga University of Medical Science, Shiga, Japan.
⁵ Department of Public Health, Shiga University of Medical Science, Shiga, Japan.
⁶ Center for the Epidemiologic Research in Asia (CERA), Shiga University of Medical Science, Shiga, Japan.
⁷ Department of Medical Statistics, Shiga University of Medical Science, Shiga, Japan.
⁸ Department of Public Health, Shiga University of Medical Science, Shiga, Japan; International Center for Nutrition and Information, National Institute of Biomedical Innovation, Health and Nutrition, Shinjuku-ku, Tokyo, Japan.
⁹ Molecular Neuroscience Research Center, Shiga University of Medical Science, Shiga, Japan.
¹⁰ Shiga University of Medical Science, Otsu, Shiga, Japan.
¹¹ Wakayama Medical University, Wakayama, Japan.
¹² Keio University, Tokyo, Japan.
¹³ Shinshu University, Matsumoto, Nagano, Japan.
¹⁴ Ehime University, Toon, Ehime, Japan.
¹⁵ Kyoto University, Kyoto, Japan.
¹⁶ University of Pittsburgh, Pittsburgh, PA, USA.
¹⁷ Temple University, Philadelphia, PA, USA.
¹⁸ Teikyo University, Tokyo, Japan.
¹⁹ Tohoku University, Sendai, Miyagi, Japan.
²⁰ Toho University, Tokyo, Japan.
²¹ University of Human Arts and Sciences, Saitama, Japan.
²² Fukuoka University, Fukuoka, Japan.
²³ Tsuruga Nursing University, Tsuruga, Fukui, Japan.
²⁴ Okayama University, Okayama, Japan.
²⁵ Doshisha University, Kyotanabe, Kyoto, Japan.
²⁶ Korea University, Seoul, South Korea.
²⁷ National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.
²⁸ Kindai University, Osakasayama, Osaka, Japan.
²⁹ National Institute of Health and Nutrition, Tokyo, Japan.
³⁰ Fudan University Shanghai, China.
³¹ Aino University, Ibaraki, Osaka, Japan.

PMID: 33278513
DOI: 10.1016/j.alcohol.2020.11.006

Abstract

The clinical implications of alcohol consumption have been extensively examined; however, its effects on brain structures in apparently healthy community-dwellers remain unclear. Therefore, we investigated the relationship between alcohol consumption and brain gray matter volume (GMV) in community-dwelling Japanese men using voxel-based morphometry (VBM). We recruited cognitively intact Japanese men, aged 40-79 years, from a population-based cohort in Shiga, Japan. Brain magnetic resonance imaging was performed, on average, 2 years after demographic and medical information was obtained in 2010-2014. A multivariable linear regression analysis of 639 men was conducted to elucidate the relationship between the amount of alcohol consumed and GMV. VBM statistics were analyzed by threshold-free cluster enhancement with a family-wise error rate of <0.05. The results obtained demonstrated that the amount of alcohol consumed was associated with lower GMV. The VBM analysis showed lower GMV within the parahippocampal, entorhinal, cingulate, insular, temporal, and frontal cortices and cerebellum in very heavy drinkers (≥42 ethanol g/day) than in non-drinkers. Furthermore, alcohol consumption was associated with a higher white matter lesion volume. These results suggest subclinical structural changes similar to alcohol-related neurological diseases.

Keywords: alcohol consumption; brain atrophy; japanese population; neuroimaging; voxel-based morphometry.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Alcohol Drinking*
Brain* / diagnostic imaging
Gray Matter / diagnostic imaging*
Humans
Japan
Magnetic Resonance Imaging
Male
Middle Aged

Grants and funding

R01 HL068200/HL/NHLBI NIH HHS/United States