The neurodevelopmental role of dopaminergic signaling in neurological disorders

Yunyun Cai; Lingyan Xing; Tuo Yang; Rui Chai; Jiaqi Wang; Jingyin Bao; Weixing Shen; Sujun Ding; Gang Chen

doi:10.1016/j.neulet.2020.135540

The neurodevelopmental role of dopaminergic signaling in neurological disorders

Neurosci Lett. 2021 Jan 10:741:135540. doi: 10.1016/j.neulet.2020.135540. Epub 2020 Dec 2.

Authors

Yunyun Cai¹, Lingyan Xing², Tuo Yang³, Rui Chai², Jiaqi Wang¹, Jingyin Bao⁴, Weixing Shen⁵, Sujun Ding⁶, Gang Chen⁷

Affiliations

¹ Department of Physiology, School of Medicine, Nantong University, Nantong, Jiangsu Province, 226001, China.
² Key Laboratory of Neuroregeneration of Jiangsu and the Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu Province, 226001, China.
³ Department of Hand Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, 130033, China.
⁴ Basic Medical Research Centre, Medical College of Nantong University, Nantong, Jiangsu Province, 226001, China.
⁵ Department of Physiology, School of Medicine, Nantong University, Nantong, Jiangsu Province, 226001, China. Electronic address: swx@ntu.edu.cn.
⁶ Department of Ultrasound, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, 226001, China. Electronic address: 631540321@qq.com.
⁷ Department of Tissue and Embryology, Medical School of Nantong University, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu Province, 226001, China; Department of Anesthesiology, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, 226001, China. Electronic address: chengang6626@ntu.edu.cn.

PMID: 33278505
DOI: 10.1016/j.neulet.2020.135540

Abstract

Dopamine (DA), a critical neurotransmitter of both the central and peripheral nerve system, plays important roles in a series of biological processes. Dysfunction of dopaminergic signalling may lead to a series of developmental disorders, including attention deficit/hyperactivity disorder, autism and schizophrenia. However, the exact roles of dopaminergic signalling in these diseases are far from fully understood. We analyse the roles of dopaminergic signalling in multiple physiological and pathological processes, focusing on brain development and related disorders. By summarizing current research in this area, we provide guidance for future studies. This review seeks to deepen our understanding of dopaminergic signalling in developmental disorders, which may offer clues for developing more effective therapeutic drugs.

Keywords: Brain development; Dopaminergic signalling; Mental disorders.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Attention Deficit Disorder with Hyperactivity / metabolism
Autism Spectrum Disorder / metabolism
Brain / growth & development*
Brain / metabolism*
Dopamine / metabolism*
Humans
Mental Disorders / metabolism*
Nervous System Diseases / metabolism*
Neurogenesis
Neurons / metabolism
Schizophrenia / metabolism
Signal Transduction

Substances

Dopamine