Ectatic diseases

Marcella Q Salomão; Ana Luisa Hofling-Lima; Louise Pellegrino Gomes Esporcatte; Fernando Faria Correa; Bernardo Lopes; Nelson Sena Jr; Daniel G Dawson; Renato Ambrósio Jr

doi:10.1016/j.exer.2020.108347

Ectatic diseases

Exp Eye Res. 2021 Jan:202:108347. doi: 10.1016/j.exer.2020.108347. Epub 2020 Dec 1.

Authors

Marcella Q Salomão¹, Ana Luisa Hofling-Lima², Louise Pellegrino Gomes Esporcatte³, Fernando Faria Correa⁴, Bernardo Lopes⁵, Nelson Sena Jr⁶, Daniel G Dawson⁷, Renato Ambrósio Jr⁸

Affiliations

¹ Instituto de Olhos Renato Ambrósio, Rio de Janeiro, Brazil; Rio de Janeiro Corneal Tomography and Biomechanics Study Group, Rio de Janeiro, Brazil; Brazilian Study Group of Artificial Intelligence and Corneal Analysis - BrAIN, Rio de Janeiro & Maceió, Brazil; Department of Ophthalmology, Escola Paulista de Medicina - Universidade Federal de São Paulo, São Paulo, Brazil; Instituto Benjamin Constant, Rio de Janeiro, Brazil. Electronic address: marcella@barravisioncenter.com.br.
² Department of Ophthalmology, Escola Paulista de Medicina - Universidade Federal de São Paulo, São Paulo, Brazil.
³ Instituto de Olhos Renato Ambrósio, Rio de Janeiro, Brazil; Rio de Janeiro Corneal Tomography and Biomechanics Study Group, Rio de Janeiro, Brazil; Department of Ophthalmology, Escola Paulista de Medicina - Universidade Federal de São Paulo, São Paulo, Brazil.
⁴ Hospital de Braga, Braga, Portugal; School of Medicine, University of Minho, Braga, Portugal.
⁵ Instituto de Olhos Renato Ambrósio, Rio de Janeiro, Brazil; Rio de Janeiro Corneal Tomography and Biomechanics Study Group, Rio de Janeiro, Brazil; Department of Ophthalmology, Escola Paulista de Medicina - Universidade Federal de São Paulo, São Paulo, Brazil; School of Engineering, University of Liverpool, Liverpool, UK.
⁶ Department of Ophthalmology, Federal University the State of Rio de Janeiro (UNIRIO), USA.
⁷ The University of Florida Department of Ophthalmology, Gainesville, FL, USA.
⁸ Instituto de Olhos Renato Ambrósio, Rio de Janeiro, Brazil; Rio de Janeiro Corneal Tomography and Biomechanics Study Group, Rio de Janeiro, Brazil; Brazilian Study Group of Artificial Intelligence and Corneal Analysis - BrAIN, Rio de Janeiro & Maceió, Brazil; Department of Ophthalmology, Escola Paulista de Medicina - Universidade Federal de São Paulo, São Paulo, Brazil; Department of Ophthalmology, Federal University the State of Rio de Janeiro (UNIRIO), USA. Electronic address: dr.renatoambrosio@gmail.com.

PMID: 33275919
DOI: 10.1016/j.exer.2020.108347

Abstract

Ectatic corneal disease (ECD) comprises a group of disorders characterized by progressive thinning and subsequent bulging of the corneal structure. Different phenotypes have been recognized, including keratoglobus, pellucid marginal degeneration (PMD), and keratoconus (KC). Keratoconus has been widely investigated throughout the years, but the advent of laser refractive surgery boosted an immediate need for more knowledge and research about ectatic diseases. This article discusses nomenclature of ectatic disease, etiology and pathogenesis, along with treatment options, with special focus ok KC and forme fruste keratoconus.

Keywords: Corneal biomechanics; Corneal ectasia; Corneal tomography; Corneal topography; Keratoconus.

Publication types

Review

MeSH terms

Cornea / pathology*
Cornea / physiopathology
Corneal Diseases / pathology*
Corneal Diseases / physiopathology
Corneal Topography
Elasticity
Humans