The Center Cannot Hold: NRF2 Battles Ferroptosis in the 3rd Dimension

Warren L Wu; Thales Papagiannakopoulos

doi:10.1016/j.molcel.2020.11.022

The Center Cannot Hold: NRF2 Battles Ferroptosis in the 3rd Dimension

Mol Cell. 2020 Dec 3;80(5):760-761. doi: 10.1016/j.molcel.2020.11.022.

Authors

Warren L Wu¹, Thales Papagiannakopoulos²

Affiliations

¹ Department of Pathology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA.
² Department of Pathology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA. Electronic address: papagt01@nyumc.org.

PMID: 33275886
DOI: 10.1016/j.molcel.2020.11.022

Abstract

Takahashi et al. (2020) conduct a focused CRISPR/Cas9 screen against NRF2 target and other redox regulatory genes in both 2D- and 3D-culture systems, uncovering a vulnerability of spheroid cancer cells deprived of extracellular matrix to undergo ferroptosis.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Cell Proliferation
Clustered Regularly Interspaced Short Palindromic Repeats
Culture
Ferroptosis*
NF-E2-Related Factor 2* / genetics
NF-E2-Related Factor 2* / metabolism
Signal Transduction

Substances

NF-E2-Related Factor 2

Abstract

Publication types

MeSH terms

Substances

Grants and funding