The BAS2IC Score: A Useful Tool to Identify Patients at High Risk of Early Progression to Severe Coronavirus Disease 2019

Charlotte Kaeuffer; Yvon Ruch; Thibaut Fabacher; Olivier Hinschberger; Joy Mootien; Magali Eyriey; Valentin Greigert; COVID-19 Alsace Study Group; Nicolas Meyer; Samira Fafi-Kremer; Nicolas Lefebvre; Yves Hansmann; Martin Martinot; François Danion

doi:10.1093/ofid/ofaa405

The BAS²IC Score: A Useful Tool to Identify Patients at High Risk of Early Progression to Severe Coronavirus Disease 2019

Open Forum Infect Dis. 2020 Sep 1;7(10):ofaa405. doi: 10.1093/ofid/ofaa405. eCollection 2020 Oct.

Authors

Charlotte Kaeuffer^{1

2}, Yvon Ruch^{1

2}, Thibaut Fabacher^{3

4}, Olivier Hinschberger⁵, Joy Mootien⁶, Magali Eyriey⁷, Valentin Greigert⁸; COVID-19 Alsace Study Group; Nicolas Meyer^{3

4}, Samira Fafi-Kremer^{2

9}, Nicolas Lefebvre^{1

2}, Yves Hansmann^{1

2}, Martin Martinot⁷, François Danion^{1

2}

Collaborators

Affiliations

¹ CHU de Strasbourg, Department of Infectious and Tropical Diseases, Strasbourg, France.
² Fédération de Médecine Translationnelle de Strasbourg, Université de Strasbourg, Strasbourg, France.
³ CHU de Strasbourg, Department of Public Health, Strasbourg, France.
⁴ Université de Strasbourg, ICube, Équipe IMAGeS, UMR7357, Strasbourg, France.
⁵ Groupe Hospitalier Régional Mulhouse Sud Alsace, Department of Internal Medicine, Mulhouse, France.
⁶ Groupe Hospitalier Régional Mulhouse Sud Alsace, Intensive Care Unit, Mulhouse, France.
⁷ Hôpitaux Civils de Colmar, Department of Infectious Diseases, Colmar, France.
⁸ CHU de Strasbourg, Department of Internal Medicine, Nouvel Hopital Civil Strasbourg, Strasbourg, France.
⁹ CHU de Strasbourg, Department of Virology, Strasbourg, France.

Abstract

We developed a score, with easily accessible data (age, sex, body mass index, dyspnea, inflammatory parameters), to predict the risk of rapid progression to severe coronavirus disease 2019. Using a cutoff of >6 points, the negative predictive value was 87%.

Keywords: C-reactive protein; COVID-19; body mass index (BMI); prognostic score; risk factors.