To Explore the Mechanism and Equivalent Molecular Group of Fuxin Mixture in Treating Heart Failure Based on Network Pharmacology

Yi-Ding Yu; Yi-Ping Xiu; Yang-Fan Li; Yi-Tao Xue

doi:10.1155/2020/8852877

To Explore the Mechanism and Equivalent Molecular Group of Fuxin Mixture in Treating Heart Failure Based on Network Pharmacology

Evid Based Complement Alternat Med. 2020 Nov 21:2020:8852877. doi: 10.1155/2020/8852877. eCollection 2020.

Authors

Yi-Ding Yu¹, Yi-Ping Xiu¹, Yang-Fan Li¹, Yi-Tao Xue²

Affiliations

¹ Shandong University of Traditional Chinese Medicine, Jinan 250014, China.
² Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250014, China.

Abstract

Fuxin mixture (FXHJ) is a prescription for the treatment of heart failure. It has been shown to be effective in clinical trials, but its active ingredients and mechanism of action are not completely clear, which limits its clinical application and international promotion. In this study, we used network pharmacology to find, conclude, and summarize the mechanism of FXHJ in the treatment of heart failure. From FXHJ, we found 39 active ingredients and 47 action targets. Next, we constructed the action network and was conducted enrichment analysis. The results showed that FXHJ mainly treated heart failure by regulating the MAPK signaling pathway, PI3KAkt signaling pathway, cAMP signaling pathway, TNF signaling pathway, toll-like receptor signaling pathway, VEGF signaling pathway, NF-kappa B signaling pathway, and the apoptotic signaling molecule BCL2. Through the research method of network pharmacology, this study summarized the preliminary experiments of the research group and revealed the probable mechanism of FXHJ in the treatment of heart failure to a certain extent, which provided some ideas for the development of new drugs.