SERS based sensor for mycotoxins detection: Challenges and improvements

Abstract

Surface-enhanced Raman spectroscopy (SERS) has become a growing ultrasensitive analytical technique to quantify toxic molecules in foodstuffs. Monitoring the levels of chemical contaminants not only ensures food security but also offers a guideline on the production, processing, and risk analysis of consumer's health protection. The objective of this study was to point out the possible challenges associated with the detection of mycotoxins in foodstuffs. Herein, we have discussed briefly as to selectivity, accuracy, precision, robustness, ruggedness, non-specific adsorption (NSA), cross-reactivity (for both label-free and the target analyte capture approaches like the application of antibody, aptamer, molecularly imprinted polymer (MIP), linear polymer affinity agents and/or specific surface-modified nanomaterials) and their potential solution.

Keywords: Accuracy and precision; Cross-reactivity; Mycotoxins; Non-specific adsorption; Selectivity; Surface-enhanced Raman spectroscopy.