The tiletamine-zolazepam mixture is a widely used anesthetic for chemical immobilization of wild mammals due to its short induction time, good muscle relaxation, smooth recovery with low convulsions occurrence, and minimal effect on respiration. An injection dose of 7-8 mg/kg of tiletamine-zolazepam has been proven to be an effective and safe immobilizing mixture for crested porcupines under field conditions. However, the occurrence of long immobilization and recovery times, with high excitement and convulsion during awakening, were recorded. In order to reduce such side effects after recovery, the effectiveness of a lower dosage (4-6 mg/kg) of tiletamine-zolazepam (Zoletil®) was tested. The results obtained confirm that the use of tiletamine-zolazepam in crested porcupine immobilization provides a quick induction, wide safety margin, and predictable awakening under field conditions. A smaller injection dosage of 5 mg/kg has been proven to be sufficient to ensure a short induction time (average: 7.1 min), with good muscle relaxation and little excitement of the animals during awakening. The lower dosage of tiletamine-zolazepam, while providing a shorter recovery time (average: 53.6 min), proves to be adequate for standard handling procedures. Furthermore, the smaller amount of tiletamine-zolazepam also ensures safe immobilization for pregnant individuals and porcupettes.
Keywords: Hystrix cristata; anesthetic; immobilization; rodent; tiletamine-zolazepam mixture.