TCR Gene Therapy: Challenges, Opportunities, and Future Directions

Cells. 2020 Dec 1;9(12):2567. doi: 10.3390/cells9122567.

Authors

Hans J Stauss¹, Maxine G B Tran²

Affiliations

¹ Division of Infection and Immunity, Institute of Immunity and Transplantation, University College London, Royal Free Hospital, London NW3 2PF, UK.
² Division of Surgery and Interventional Science, University College London, Royal Free Hospital, London NW3 2PF, UK.

Abstract

Adoptive immunotherapy with gene-engineered T cells has provided new treatment options for cancer patients [...].

Publication types

Editorial

MeSH terms

Antigens, Neoplasm / immunology
CD4-Positive T-Lymphocytes / immunology
CD8-Positive T-Lymphocytes / immunology
Genetic Therapy / methods
Humans
Immunotherapy, Adoptive / methods
Neoplasms / immunology
Receptors, Antigen, T-Cell / immunology*
Receptors, Chimeric Antigen / immunology
T-Lymphocytes / immunology*
Tumor Microenvironment / immunology

Substances

Antigens, Neoplasm
Receptors, Antigen, T-Cell
Receptors, Chimeric Antigen