XIST: A Meaningful Long Noncoding RNA in NSCLC Process

Yujie Shen; Yexiang Lin; Kai Liu; Jinlan Chen; Juanjuan Zhong; Yisong Gao; Chengfu Yuan

doi:10.2174/1381612826999201202102413

XIST: A Meaningful Long Noncoding RNA in NSCLC Process

Curr Pharm Des. 2021;27(11):1407-1417. doi: 10.2174/1381612826999201202102413.

Authors

Yujie Shen¹, Yexiang Lin¹, Kai Liu¹, Jinlan Chen¹, Juanjuan Zhong¹, Yisong Gao¹, Chengfu Yuan¹

Affiliation

¹ College of Medical Science, China Three Gorges University, Yichang 443002, China.

PMID: 33267757
DOI: 10.2174/1381612826999201202102413

Abstract

Background: A number of studies have proposed that lncRNA XIST plays a role in the development and chemosensitivity of NSCLC. Besides, XIST may become a potential therapeutic target for NSCLC patients. The aim of this review is to reveal the biological functions and exact mechanisms of XIST in NSCLC.

Methods: In this review, relevant researches involving the relationship between XIST and NSCLC are collected through systematic retrieval of PubMed.

Results: XIST is an oncogene in NSCLC and is abnormally upregulated in NSCLC tissues. Considerable evidence has shown that XIST plays a critical role in the proliferation, invasion, migration, apoptosis and chemosensitivity of NSCLC cells. XIST mainly functions as a ceRNA in the NSCLC process, while XIST also functions at transcriptional levels.

Conclusion: LncRNA XIST has the potential to become a novel biomolecular marker of NSCLC and a therapeutic target for NSCLC.

Keywords: NSCLC; RNA; XIST; biomolecular marker; noncoding; therapeutic target.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Carcinoma, Non-Small-Cell Lung* / drug therapy
Carcinoma, Non-Small-Cell Lung* / genetics
Cell Proliferation
Gene Expression Regulation, Neoplastic
Humans
Lung Neoplasms* / drug therapy
Lung Neoplasms* / genetics
MicroRNAs*
RNA, Long Noncoding / genetics*

Substances

MicroRNAs
RNA, Long Noncoding
XIST non-coding RNA