Estimation of Absolute Bioavailability of the Chemical Substance of the Anti-Smallpox Preparation NIOCH-14 in Mice

O Yu Mazurkov; L N Shishkina; N I Bormotov; M O Skarnovich; O A Serova; N A Mazurkova; A A Chernonosov; A Ya Tikhonov; B A Selivanov

doi:10.1007/s10517-020-05034-x

Estimation of Absolute Bioavailability of the Chemical Substance of the Anti-Smallpox Preparation NIOCH-14 in Mice

Bull Exp Biol Med. 2020 Dec;170(2):207-210. doi: 10.1007/s10517-020-05034-x. Epub 2020 Dec 2.

Authors

O Yu Mazurkov¹, L N Shishkina², N I Bormotov², M O Skarnovich², O A Serova², N A Mazurkova², A A Chernonosov³, A Ya Tikhonov⁴, B A Selivanov⁴

Affiliations

¹ State Research Center of Virology and Biotechnology "Vector", Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Koltsovo, Novosibirsk region, Russia. mazurkov_oyu@vector.nsc.ru.
² State Research Center of Virology and Biotechnology "Vector", Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Koltsovo, Novosibirsk region, Russia.
³ Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
⁴ N. N. Vo-rozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia.

PMID: 33263846
DOI: 10.1007/s10517-020-05034-x

Abstract

We compared absolute bioavailability of the chemical substance of the anti-smallpox preparation NIOCH-14 and chemical compound ST-246 active against orthopoxviruses after oral administration to mice in doses of 10 and 50 μg/g and intravenous administration to mice in a dose of 2 μg/g body weight. The absolute bioavailability of NIOCH-14 is comparable with the absolute bioavailability of ST-246.

Keywords: anti-smallpox preparations; bioavailability; mice; pharmacokinetics.

MeSH terms

Animals
Area Under Curve
Benzamides / pharmacokinetics
Biological Availability*
Calibration
Dicarboxylic Acids / pharmacokinetics*
Disease Models, Animal
Female
Infusions, Intravenous
Isoindoles / pharmacokinetics
Male
Mice
Mice, Inbred ICR
Smallpox / drug therapy*
Time Factors
Variola virus

Substances

Benzamides
Dicarboxylic Acids
Isoindoles
NIOCH-14
tecovirimat