Association of Insulin Resistance With Depression Severity and Remission Status: Defining a Metabolic Endophenotype of Depression

JAMA Psychiatry. 2021 Apr 1;78(4):439-441. doi: 10.1001/jamapsychiatry.2020.3669.

Authors

Kathleen T Watson^{1

2}, Julia F Simard¹, Victor W Henderson^{1

3}, Lexi Nutkiewicz², Femke Lamers⁴, Natalie Rasgon², Brenda Penninx⁴

Affiliations

¹ Department of Epidemiology and Population Health, Stanford School of Medicine, Stanford, California.
² Department of Psychiatry and Behavioral Sciences, Stanford School of Medicine, Stanford, California.
³ Department of Neurology and Neurological Sciences, Stanford University, Stanford, California.
⁴ Department of Psychiatry and Amsterdam Public Health Research Institute, Amsterdam, the Netherlands.

Abstract

This study investigates whether insulin resistance was positively associated with the presence, severity, or chronicity of major depression.

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Cross-Sectional Studies
Depressive Disorder, Major / blood*
Depressive Disorder, Major / epidemiology
Depressive Disorder, Major / physiopathology*
Endophenotypes*
Female
Humans
Insulin Resistance / physiology*
Male
Middle Aged
Netherlands / epidemiology
Patient Acuity
Remission Induction

Grants and funding

P50 AG047366/AG/NIA NIH HHS/United States