Value of Placental Examination in the Diagnostic Evaluation of Stillbirth

Fetal Pediatr Pathol. 2022 Aug;41(4):535-550. doi: 10.1080/15513815.2020.1850952. Epub 2020 Dec 2.

Abstract

ObjectiveThe aim was to assess the contribution of placental examination in the etiologic investigation of stillbirth. Materials and Methods: A retrospective review of stillbirths that occurred after 14 weeks gestation was conducted for a one-year period. Twin pregnancies and fetuses without placentas were excluded. According to the fetoplacental examination, stillbirths were classified into etiologic groups. Results: A total of 147 stillbirths were selected. They were associated with placental, materno-fetal, fetal and multiple causes in 89 cases (61%), 23 cases (16%), 14 cases (9%) and 13 cases (9%), respectively. Unexplained stillbirths were observed in 8 cases (5%). Placental abnormalities were identified in 132/147 cases (90%). They were consistent with vascular, inflammatory and developmental lesions in 82/132 cases (61%), 28/132 cases (21%) and 18/132 cases (13%), respectively. Conclusion: Placental lesions were the main causes of stillbirth and were predominantly of vascular type including chronic villous hypoxia-ischemia and funicular anomalies.

Keywords: Stillbirth; fetus; histology; infection; ischemia; malformations; placenta.

MeSH terms

  • Female
  • Gestational Age
  • Humans
  • Placenta / pathology
  • Placenta Diseases* / diagnosis
  • Placenta Diseases* / pathology
  • Pregnancy
  • Retrospective Studies
  • Stillbirth*