Structure-based development of human antibody cocktails against SARS-CoV-2

Nan Wang; Yao Sun; Rui Feng; Yuxi Wang; Yan Guo; Li Zhang; Yong-Qiang Deng; Lei Wang; Zhen Cui; Lei Cao; Yan-Jun Zhang; Weimin Li; Feng-Cai Zhu; Cheng-Feng Qin; Xiangxi Wang

doi:10.1038/s41422-020-00446-w

Structure-based development of human antibody cocktails against SARS-CoV-2

Cell Res. 2021 Jan;31(1):101-103. doi: 10.1038/s41422-020-00446-w. Epub 2020 Dec 1.

Authors

Nan Wang^#^{1

2}, Yao Sun^#¹, Rui Feng^#^{1

2}, Yuxi Wang^#³, Yan Guo^#⁴, Li Zhang^#⁵, Yong-Qiang Deng⁴, Lei Wang¹, Zhen Cui¹, Lei Cao¹, Yan-Jun Zhang⁶, Weimin Li⁷, Feng-Cai Zhu⁸, Cheng-Feng Qin⁹, Xiangxi Wang^{10

11

12}

Affiliations

¹ CAS Key Laboratory of Infection and Immunity, National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
² University of Chinese Academy of Sciences, Beijing, 100049, China.
³ Department of Respiratory and Critical Care Medicine, West China Medical School/West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
⁴ State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, AMMS, Beijing, 100071, China.
⁵ National Health Commission of the People's Republic of China, Key laboratory of Enteric Pathogenic Microbiology (Jiangsu Provincial Center for Disease Control and Prevention), Nanjing, Jiangsu, 210009, China.
⁶ Department of Microbiology, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang, 310000, China.
⁷ Department of Respiratory and Critical Care Medicine, West China Medical School/West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China. weimi003@scu.edu.cn.
⁸ National Health Commission of the People's Republic of China, Key laboratory of Enteric Pathogenic Microbiology (Jiangsu Provincial Center for Disease Control and Prevention), Nanjing, Jiangsu, 210009, China. jszfc@vip.sina.com.
⁹ State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, AMMS, Beijing, 100071, China. qincf@bmi.ac.cn.
¹⁰ CAS Key Laboratory of Infection and Immunity, National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China. xiangxi@ibp.ac.cn.
¹¹ University of Chinese Academy of Sciences, Beijing, 100049, China. xiangxi@ibp.ac.cn.
¹² Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, Guangdong, 510200, China. xiangxi@ibp.ac.cn.

^# Contributed equally.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Antibodies, Neutralizing / immunology*
Antibodies, Neutralizing / therapeutic use
Antibodies, Viral / immunology*
Antibodies, Viral / therapeutic use
COVID-19 / immunology*
COVID-19 Drug Treatment
Humans
SARS-CoV-2 / immunology*
Spike Glycoprotein, Coronavirus / immunology*

Substances

Antibodies, Neutralizing
Antibodies, Viral
Spike Glycoprotein, Coronavirus