Successful hematopoietic stem cell transplantation in a 4-1BB deficient patient with EBV-induced lymphoproliferation

Clin Immunol. 2021 Jan:222:108639. doi: 10.1016/j.clim.2020.108639. Epub 2020 Nov 28.

Abstract

Complete remission from recurrent EBV-positive lymphoma is not mandatory before HSCT to achieve long-term cure in a patient suffering from a recently described immunodeficiency affecting the T-cell coactivation molecule 4-1BB.

Keywords: 4-1BB; Epstein Barr virus; HSCT; Recurrent lymphoproliferation.

Publication types

  • Case Reports
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • 4-1BB Ligand / deficiency*
  • Child
  • Epstein-Barr Virus Infections / pathology*
  • Epstein-Barr Virus Infections / therapy
  • Hematopoietic Stem Cell Transplantation*
  • Herpesvirus 4, Human / isolation & purification
  • Humans
  • Lymphoma, B-Cell / pathology
  • Lymphoma, B-Cell / therapy*
  • Male
  • Tumor Necrosis Factor Receptor Superfamily, Member 9 / genetics*

Substances

  • 4-1BB Ligand
  • TNFRSF9 protein, human
  • Tumor Necrosis Factor Receptor Superfamily, Member 9