Hypergonadotropic hypogonadism after ovarian tissue cryopreservation on a 13-year-old female: A case report and review of the literature

Dehlia Moussaoui; Julie Bénard; Michal Yaron; Fanette Bernard; Cécile Adam; Nicolas Vulliemoz; Thérèse Bouthors; Véronique Andrey; Marc Ansari; Céline Girardin; Fabienne Gumy-Pause

doi:10.1016/j.jogoh.2020.102029

Hypergonadotropic hypogonadism after ovarian tissue cryopreservation on a 13-year-old female: A case report and review of the literature

J Gynecol Obstet Hum Reprod. 2021 Feb;50(2):102029. doi: 10.1016/j.jogoh.2020.102029. Epub 2020 Nov 28.

Authors

Affiliations

¹ Division of General Pediatrics, Department of Woman, Child and Adolescent Medicine, Geneva University Hospitals, Geneva, Switzerland. Electronic address: dehlia.moussaoui@hcuge.ch.
² Division of Gynecology, Department of Woman, Child and Adolescent Medicine, Geneva University Hospitals, Geneva, Switzerland.
³ Pediatric Onco-Hematology Unit, Department of Woman, Child and Adolescent Medicine, Geneva University Hospitals, Geneva, Switzerland; CANSEARCH Research Laboratory, Department of Woman, Child and Adolescent Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
⁴ Division of Pediatrics, Oncology and Hematology Unit, Woman-Mother-Child Department, Lausanne University Hospital, Lausanne, Switzerland.
⁵ Fertility Medicine and Gynecologic Endocrinology Unit, Woman-Mother-Child Department, Lausanne University Hospital, Lausanne, Switzerland.
⁶ Division of Pediatrics, Pediatric Endocrinology and Diabetology Unit, Woman-Mother-Child Department, Lausanne University Hospital, Lausanne, Switzerland.
⁷ Division of Pediatric Surgery, Woman-Mother-Child Department, Lausanne University Hospital, Lausanne, Switzerland.
⁸ Pediatric Endocrine and Diabetes Unit, Department of Woman, Child and Adolescent Medicine, Geneva University Hospitals, Geneva, Switzerland.

PMID: 33259962
DOI: 10.1016/j.jogoh.2020.102029

Abstract

Ovarian failure is a major long-term adverse event following gonadotoxic treatment of malignant diseases. Ovarian tissue cryopreservation can be offered in some conditions to preserve fertility. We report the case of a 13-year-old female with a diagnosis of acute myeloid leukemia, who presented with hypergonadotropic hypogonadism after unilateral ovariectomy for fertility preservation and before highly gonadotoxic treatment. Even though damage seemed only partial, this case suggests that the remaining contralateral ovarian function may be compromised after ovarian tissue cryopreservation, leading per se to a hypergonadotropic hypogonadism. Although indication of ovarian cryopreservation is not called into question in situations of highly gonadotoxic therapy, this procedure should only be performed after evaluation by a specialized multidisciplinary team and provided a solid indication.

Keywords: Fertility preservation; Gonadotoxic treatment; Hypergonadotropic hypogonadism; Oncofertility; Ovarian failure; Ovarian tissue cryopreservation.

Publication types

Case Reports
Review

MeSH terms

Adolescent
Cryopreservation*
Female
Fertility Preservation*
Humans
Hypogonadism / etiology*
Leukemia, Myeloid, Acute / therapy
Ovariectomy*