The role of non-coding genome in the behavior of infiltrated myeloid-derived suppressor cells in tumor microenvironment; a perspective and state-of-the-art in cancer targeted therapy

Arezoo Gowhari Shabgah; Arash Salmaninejad; Lakshmi Thangavelu; Markov Alexander; Alexei Valerievich Yumashev; Pouya Goleij; Mahdiyeh Hedayati-Moghadam; Hamed Mohammadi; Majid Ahmadi; Jamshid Gholizadeh Navashenaq

doi:10.1016/j.pbiomolbio.2020.11.006

The role of non-coding genome in the behavior of infiltrated myeloid-derived suppressor cells in tumor microenvironment; a perspective and state-of-the-art in cancer targeted therapy

Prog Biophys Mol Biol. 2021 May:161:17-26. doi: 10.1016/j.pbiomolbio.2020.11.006. Epub 2020 Nov 28.

Affiliations

¹ School of Medicine, Bam University of Medical Sciences, Bam, Iran; Student Research Committee, Bam University of Medical Sciences, Bam, Iran.
² Department of Medical Genetics, Medical Genetics Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
³ Department of Pharmacology, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.
⁴ Tyumen State Medical University, Tyumen, Russian Federation.
⁵ Department of Prosthetic Dentistry, Sechenov First Moscow State Medical University, Moscow, Russian Federation.
⁶ Sana Institute of Higher Education, Faculty of Biology, Department of Genetics, Sari, Iran.
⁷ Department of Physiology, School of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran.
⁸ Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran; Department of Immunology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran.
⁹ Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
¹⁰ Student Research Committee, Bam University of Medical Sciences, Bam, Iran; Noncommunicable Diseases Research Center, Bam University of Medical Sciences, Bam, Iran. Electronic address: jamshid.gholizadeh@mubam.ac.ir.

PMID: 33259833
DOI: 10.1016/j.pbiomolbio.2020.11.006

Abstract

Cancer is one of the healthcare problems that affect many communities around the world. Many factors contribute to cancer development. Besides, these factors are counted as the main impediment in cancer immunotherapy. Myeloid-derived suppressor cells (MDSCs) are one of these impediments. MDSCs inhibit the immune responses through various mechanisms such as inhibitory cytokine release and nitric oxide metabolite production. Several factors are involved in forming these cells, including tumor secreted cytokine and chemokines, transcription factors, and non-coding RNA. In the meantime, micro-RNAs (miRNAs) and long non-coding RNAs (lncRNAs) are the vital gene regulatory elements that affect gene expression. In this study, we are going to discuss the role of miRNAs and lncRNAs in MDSCs development in a cancer situation. It is hoped that miRNA and lncRNAs targeting may prevent the growth and development of these inhibitory cells in the cancer environment.

Keywords: Cancer; Immunosuppression; MDSC; lncRNA; miRNA.

Publication types

Review

MeSH terms

Humans
Immunotherapy
MicroRNAs / genetics
Myeloid-Derived Suppressor Cells*
Neoplasms* / genetics
Neoplasms* / therapy
Tumor Microenvironment*

Substances

MicroRNAs