Entanglement plays a central role in quantum information processing and quantum physics. However, few effective ways are known to detect the amount of entanglement of an unknown quantum state. Here, we propose a scheme to estimate the entanglement negativity for any bipartition of a composite system. The proposed scheme is based on the random unitary evolution and local measurements on a single-copy quantum state, which is more practical compared to former methods based on collective measurements on many copies of the identical state. Meanwhile, we generalize the scheme to quantify the total correlation. We demonstrate the efficiency of the scheme with statistical analyses and numerical simulations. Our scheme is quite suitable for state-of-the-art quantum platforms, which can serve as a useful benchmarking tool to advance quantum technologies and a probe to study fundamental quantum physics like entanglement dynamics.