Surgical Treatment of Medication-Related Osteonecrosis of the Jaw: A Retrospective Study

Int J Environ Res Public Health. 2020 Nov 26;17(23):8801. doi: 10.3390/ijerph17238801.

Abstract

The purpose of this study was to confirm the success rate of surgical treatment of medication-related osteonecrosis of the jaw (MRONJ) in patients at a single institution (Association of Oral and Maxillofacial Surgery (AAOMS) stages 1, 2, or 3), and to identify the factors that influence treatment outcomes. As a result of analyzing the outcomes of treatment, surgical "success" was achieved in 93.97% (109) of cases, and "failure" was observed at 6.03% (7) cases. Analysis of patient factors that potentially affect treatment outcomes showed that zoledronate dose (p = 0.005) and the IV (intravenous) injection of drugs (p = 0.044) had significant negative impacts.

Keywords: MRONJ; bisphosphonate; osteoporosis; surgical treatment.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Bisphosphonate-Associated Osteonecrosis of the Jaw* / surgery
  • Bone Density Conservation Agents* / adverse effects
  • Diphosphonates / adverse effects
  • Female
  • Humans
  • Male
  • Middle Aged
  • Pharmaceutical Preparations*
  • Retrospective Studies

Substances

  • Bone Density Conservation Agents
  • Diphosphonates
  • Pharmaceutical Preparations