Copper containing silicocarnotite bioceramic with improved mechanical strength and antibacterial activity

Shunxiang Xu; Qiang Wu; Yaping Guo; Congqin Ning; Kerong Dai

doi:10.1016/j.msec.2020.111493

Copper containing silicocarnotite bioceramic with improved mechanical strength and antibacterial activity

Mater Sci Eng C Mater Biol Appl. 2021 Jan:118:111493. doi: 10.1016/j.msec.2020.111493. Epub 2020 Sep 8.

Authors

Shunxiang Xu¹, Qiang Wu², Yaping Guo³, Congqin Ning⁴, Kerong Dai²

Affiliations

¹ The Education Ministry Key Lab of Resource Chemistry and Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Normal University, Shanghai, China; State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, China.
² Shanghai Key Laboratory of Orthopaedic Implant, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai, China.
³ The Education Ministry Key Lab of Resource Chemistry and Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Normal University, Shanghai, China.
⁴ The Education Ministry Key Lab of Resource Chemistry and Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Normal University, Shanghai, China; State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, China. Electronic address: cqning@shnu.edu.cn.

PMID: 33255060
DOI: 10.1016/j.msec.2020.111493

Abstract

Copper is well known for its multifunctional biological effects including antibacterial and angiogenic activities, while silicon-containing bioceramic has proved to possess superior biological properties to hydroxyapatite (HA). In this work, CuO was introduced to silicocarnotite (Ca₅(PO₄)₂SiO₄, CPS) to simultaneously enhance its mechanical and antibacterial properties, and its cytocompatibility was also evaluated. Results showed that CuO could significantly facilitate the densification process of CPS bioceramic through liquid-phase sintering. The bending strength of CPS with the addition of 3.0 wt% CuO improved from 29.2 MPa to 63.4 MPa after sintered at 1200 °C. Moreover, Cu-CPS bioceramics demonstrated superior in vitro antibacterial property against both S. aureus and E. coli strains by destroying their membrane integrity, and the antibacterial activity augmented with CuO content. Meanwhile, the released Cu ions from Cu-CPS bioceramics could promote the proliferation of human umbilical vein endothelial cells (HUVECs), and the in vitro cytocompatibility exhibited concentration dependence on Cu ions. These suggest that Cu-CPS bioceramics might be promising candidates for bone tissue regeneration with an ability to prevent postoperative infections.

Keywords: Antibacterial property; Copper oxide; Cytocompatibility; Mechanical strength; Silicocarnotite.

MeSH terms

Anti-Bacterial Agents / pharmacology
Calcium Phosphates
Copper* / pharmacology
Escherichia coli
Humans
Silicates
Staphylococcus aureus*

Substances

Anti-Bacterial Agents
Calcium Phosphates
Silicates
silicocarnotite
Copper