Nudix proteins affecting microbial pathogenesis

Microbiology (Reading). 2020 Dec;166(12):1110-1114. doi: 10.1099/mic.0.000993.

Abstract

Nudix proteins catalyse hydrolysis of pyrophosphate bonds in a variety of substrates and are ubiquitous in all domains of life. Their widespread presence and broad substrate specificity suggest that they have important cellular functions. In this review, we summarize the state of knowledge on microbial Nudix proteins involved in pathogenesis.

Keywords: Nudix enzymes; pathogenesis; pyrophosphate bond.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Bacterial Proteins / chemistry
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism
  • Diphosphates / metabolism
  • Nudix Hydrolases
  • Pyrophosphatases / chemistry
  • Pyrophosphatases / genetics
  • Pyrophosphatases / metabolism*
  • Sequence Alignment
  • Viral Proteins / chemistry
  • Viral Proteins / genetics
  • Viral Proteins / metabolism
  • Virulence
  • Virulence Factors / chemistry
  • Virulence Factors / genetics
  • Virulence Factors / metabolism*

Substances

  • Bacterial Proteins
  • Diphosphates
  • Viral Proteins
  • Virulence Factors
  • diphosphoric acid
  • Pyrophosphatases