Anti-proliferative activities of coumarins from the Thai medicinal plant Mammea siamensis (Miq.) T. Anders. against human digestive tract carcinoma cell lines

Fenglin Luo; Hidemi Sugita; Kenichi Muraki; Shunsuke Saeki; Saowanee Chaipech; Yutana Pongpiriyadacha; Osamu Muraoka; Toshio Morikawa

doi:10.1016/j.fitote.2020.104780

Anti-proliferative activities of coumarins from the Thai medicinal plant Mammea siamensis (Miq.) T. Anders. against human digestive tract carcinoma cell lines

Fitoterapia. 2021 Jan:148:104780. doi: 10.1016/j.fitote.2020.104780. Epub 2020 Nov 25.

Authors

Fenglin Luo¹, Hidemi Sugita¹, Kenichi Muraki¹, Shunsuke Saeki¹, Saowanee Chaipech², Yutana Pongpiriyadacha³, Osamu Muraoka¹, Toshio Morikawa⁴

Affiliations

¹ Pharmaceutical Research and Technology Institute, Kindai University, 3-4-1 Kowakae, Higashi-osaka, Osaka 577-8502, Japan.
² Pharmaceutical Research and Technology Institute, Kindai University, 3-4-1 Kowakae, Higashi-osaka, Osaka 577-8502, Japan; Faculty of Agro-Industry, Rajamangala University of Technology Srivijaya, Thungyai, Nakhon Si Thammarat 80240, Thailand.
³ Faculty of Science and Technology, Rajamangala University of Technology Srivijaya, Thungyai, Nakhon Si Thammarat 80240, Thailand.
⁴ Pharmaceutical Research and Technology Institute, Kindai University, 3-4-1 Kowakae, Higashi-osaka, Osaka 577-8502, Japan. Electronic address: morikawa@kindai.ac.jp.

PMID: 33246033
DOI: 10.1016/j.fitote.2020.104780

Abstract

Geranylated coumarins named mammeasins G-J (1-4) were isolated from the methanol extract of the flowers of Mammea siamensis (Miq.) T. Anders. (Calophyllaceae) originating in Thailand. Their structures were established based on detailed spectroscopic analyses. The isolates, including previously reported coumarin constituents (5-28), exhibited anti-proliferative activities against human carcinoma cell lines HSC-2, HSC-4, MKN-45, and MCF-7. Mammeasin A (7, IC₅₀ = 13.6 μM) and surangin B (15, 15.2 μM), both consisting of the geranyl group, were found to show relatively strong activities against HSC-4 cells and their mechanisms of action were found to involve apoptotic cell death.

Keywords: Anti-proliferative activity; Calophyllaceae; Geranylated coumarin; Mammea siamensis; Mammeasin.

MeSH terms

Antineoplastic Agents, Phytogenic / isolation & purification
Antineoplastic Agents, Phytogenic / pharmacology*
Apoptosis
Carcinoma / drug therapy
Carcinoma / pathology
Cell Line, Tumor
Coumarins / isolation & purification
Coumarins / pharmacology*
Flowers / chemistry
Gastrointestinal Neoplasms / drug therapy
Gastrointestinal Neoplasms / pathology*
Humans
Mammea / chemistry*
Molecular Structure
Phytochemicals / isolation & purification
Phytochemicals / pharmacology
Plants, Medicinal / chemistry
Thailand

Substances

Antineoplastic Agents, Phytogenic
Coumarins
Phytochemicals
surangin B