Bidirectional and dynamic interaction between the microbiota and therapeutic resistance in pancreatic cancer

Jia Dong; He-Li Gao; Wen-Quan Wang; Xian-Jun Yu; Liang Liu

doi:10.1016/j.bbcan.2020.188484

Bidirectional and dynamic interaction between the microbiota and therapeutic resistance in pancreatic cancer

Biochim Biophys Acta Rev Cancer. 2021 Jan;1875(1):188484. doi: 10.1016/j.bbcan.2020.188484. Epub 2020 Nov 24.

Authors

Jia Dong¹, He-Li Gao¹, Wen-Quan Wang¹, Xian-Jun Yu², Liang Liu³

Affiliations

¹ Department of Pancreatic Surgery, Shanghai Cancer Centre, Fudan University, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China; Shanghai Pancreatic Cancer Institute, Shanghai, China; Pancreatic Cancer Institute, Fudan University, Shanghai, China.
² Department of Pancreatic Surgery, Shanghai Cancer Centre, Fudan University, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China; Shanghai Pancreatic Cancer Institute, Shanghai, China; Pancreatic Cancer Institute, Fudan University, Shanghai, China. Electronic address: yuxianjun@fudanpci.org.
³ Department of Pancreatic Surgery, Shanghai Cancer Centre, Fudan University, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China; Shanghai Pancreatic Cancer Institute, Shanghai, China; Pancreatic Cancer Institute, Fudan University, Shanghai, China. Electronic address: liuliang@fudanpci.org.

PMID: 33246025
DOI: 10.1016/j.bbcan.2020.188484

Abstract

Pancreatic ductal adenocarcinoma is one of the most lethal malignancies and is known for its high resistance and low response to treatment. Cancer treatments can reshape the microbiota and in turn, the microbiota influences the therapeutic efficacy by regulating immune response and metabolism. This crosstalk is bidirectional, heterogeneous, and dynamic. In this review, we elaborated on the interactions between the microbiota and therapeutic resistance in pancreatic ductal adenocarcinoma. Regulating the microbiota in pancreatic tumor microenvironment may not only generate direct anti-cancer but also synergistic effects with other treatments, providing new directions in cancer therapy.

Keywords: Immunotherapy; Microbiomes; Pancreatic cancer; Therapeutic resistance.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Adenocarcinoma / drug therapy*
Adenocarcinoma / immunology
Adenocarcinoma / microbiology
Carcinoma, Pancreatic Ductal / drug therapy*
Carcinoma, Pancreatic Ductal / immunology
Carcinoma, Pancreatic Ductal / microbiology
Drug Resistance, Neoplasm / genetics*
Drug Resistance, Neoplasm / immunology
Gastrointestinal Microbiome / genetics*
Gastrointestinal Microbiome / immunology
Humans
Immunity / drug effects
Immunity / immunology
Tumor Microenvironment / drug effects
Tumor Microenvironment / immunology