Magnetic Resonance Imaging and Histopathologic Findings From a Standard Poodle With Neonatal Encephalopathy With Seizures

Yoshihiko Yu; Daisuke Hasegawa; James K Chambers; Kazuhiro Kojima; Rikako Asada; Gary S Johnson; Kazuyuki Uchida

doi:10.3389/fvets.2020.578936

Magnetic Resonance Imaging and Histopathologic Findings From a Standard Poodle With Neonatal Encephalopathy With Seizures

Front Vet Sci. 2020 Nov 10:7:578936. doi: 10.3389/fvets.2020.578936. eCollection 2020.

Authors

Yoshihiko Yu¹, Daisuke Hasegawa^{1

2}, James K Chambers³, Kazuhiro Kojima³, Rikako Asada¹, Gary S Johnson⁴, Kazuyuki Uchida³

Affiliations

¹ Laboratory of Veterinary Radiology, Nippon Veterinary and Life Science University, Tokyo, Japan.
² The Research Center for Animal Life Science, Nippon Veterinary and Life Science University, Tokyo, Japan.
³ Laboratory of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
⁴ Department of Veterinary Pathobiology, University of Missouri, Columbia, MO, United States.

Abstract

Neonatal encephalopathy with seizures (NEwS) is an epileptic encephalopathy with an autosomal recessive inheritance pattern found in Standard Poodle puppies. The causal genetic variant for NEwS has been identified as a homozygous missense mutation in ATF2 (c.152T>G, p.Met51Arg), and a pathological cerebellar change has been reported. Magnetic resonance imaging showed reduced whole-brain size, dilated ventricles, developmental abnormalities of the white matter of the cerebrum, white matter signal abnormalities in the occipital lobe, and abnormal morphology of the cerebellum. Histopathology included previously unrecognized irregular neuronal migration in the subventricular zone around the lateral ventricles in the frontal lobe and white matter rarefaction especially at the level of the occipital lobe in the cerebrum in addition to the cerebellar cortical dysplasia that has been previously described. The findings of this case may highlight the critical role of ATF2 in neurodevelopmental processes in the canine brain.

Keywords: ATF2; EEG; MRI; activating transcription factor 2; canine; dog; epilepsy.

Publication types

Case Reports