Effects of Ten-Eleven Translocation-2 (Tet2) on myogenic differentiation of chicken myoblasts

Comp Biochem Physiol B Biochem Mol Biol. 2021 Feb-Mar:252:110540. doi: 10.1016/j.cbpb.2020.110540. Epub 2020 Nov 24.

Abstract

Skeletal muscle development is an orchestrated progress that is primarily regulated by temporospatial expression of myogenic regulatory factors (MRFs). Recent studies demonstrated that DNA demethylation also exerted a critical role in myogenesis. However, the function of Tet2 in the regulation of chicken myogenesis still remains unknown. In the present study, the role of Tet2 in regulating myogenic differentiation was determined by using a model of primary myoblasts from chickens. The expression of Tet2 was significantly elevated during myoblast differentiation. Meanwhile, the level of 5hmC in genomic DNA was increased, but H3K9me2 and H3K27me3 were markedly reduced following differentiation. Knockdown of Tet2 significantly inhibited the formation of multinucleated myotubes, which was accompanied by a reduction of relevant pivotal MRFs. Moreover, the level of 5hmC decreased sharply in Tet2 knockdown myoblasts. Attenuated differentiated myoblasts that resulted from reduced Tet2 also demonstrated an increased level of H3K9me2 and H3K27me3. Collectively, these results indicated that Tet2 played an essential role during myogenesis, which affected demethylation of genomic DNA and histone to regulate expression of MRFs and therefore, contributed to myoblast differentiation.

Keywords: DNA demethylation; Histone demethylation; MRFs; Myoblast differentiation; Tet2.

MeSH terms

  • Animals
  • Cell Differentiation*
  • Cells, Cultured
  • Chickens
  • DNA Methylation*
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism*
  • Gene Knockdown Techniques
  • Models, Animal
  • Muscle Development / physiology*
  • Muscle Fibers, Skeletal / cytology*
  • Muscle Fibers, Skeletal / metabolism
  • Myoblasts / cytology*
  • Myoblasts / metabolism

Substances

  • DNA-Binding Proteins