Delayed Anterior Cruciate Ligament Reconstruction Increases the Risk of Abnormal Prereconstruction Laxity, Cartilage, and Medial Meniscus Injuries

Abstract

Purpose: To determine the association between a delay in anterior cruciate ligament reconstruction (ACLR), age, sex, body mass index (BMI) and cartilage injuries, meniscus injuries, meniscus repair, and abnormal prereconstruction laxity.

Methods: Patients who underwent primary ACLR at our institution from January 2005 to March 2017, with no associated ligament injuries, were identified. Logistic regression analyses were used to evaluate whether delay in ACLR, age, sex, and BMI were risk factors for cartilage and meniscus injuries, meniscus repair, and abnormal (side-to-side difference >5 mm) prereconstruction laxity.

Results: A total of 3976 patients (mean age 28.6 ± 10.6 years, range 10-61 years) were included. The risk of cartilage injury increased with a delay in ACLR (12-24 months: odds ratio [OR] 1.20; 95% confidence interval [CI] 1.05-1.29; P = .005; and > 24 months: OR 1.20; 95% CI 1.11-1.30; P < .001) and age ≥30 years (OR 2.27; 95% CI 1.98-2.60; P < .001). The risk of medial meniscus (MM) injury increased with a delay in ACLR (12-24 months: OR 1.20; 95% CI 1.07-1.29; P = .001; and >24 months: OR 1.22; 95% CI 1.13-1.30; P < .001), male sex (OR 1.16; 95% CI 1.04-1.30; P = .04) and age ≥30 years (OR 1.20; 95% CI 1.04-1.33; P = .008). The risk of lateral meniscus (LM) injury decreased with a delay in ACLR of >3 months and age ≥30 years (OR 0.75; 95% CI 0.66-0.85; P < .001), whereas it increased with male sex (OR 1.32; 95% CI 1.22-1.41; P < .001). MM repairs relative to MM injury decreased with a delay in ACLR (6-12 months: OR 0.70; 95% CI 0.54-0.92; P = .01; 12-24 months: OR 0.69; 95% CI 0.57-0.85; P < .001; >24 months: OR 0.61; 95% CI 0.52-0.72; P < .001) and age ≥30 years (OR 0.60; 95% CI 0.48-0.74; P < .001). LM repairs relative to LM injury only decreased with age ≥30 years (OR 0.34; 95% CI 0.26-0.45; P < .001). The risk of having abnormal knee laxity increased with a delay in ACLR of >6 months and MM injury (OR 1.52; 95% CI 1.16-1.97; P = .002), whereas it decreased with a BMI of ≥25 (OR 0.68; 95% CI 0.52-0.89; P = .006).

Conclusions: A delay in ACLR of >12 months increased the risk of cartilage and MM injuries, whereas a delay of >6 months increased the risk of abnormal prereconstruction laxity and reduced the likelihood of MM repair. To reduce meniscus loss and the risk of jeopardizing knee laxity, ACLR should be performed within 6 months after the injury.

Level of evidence: Level III, retrospective therapeutic comparative study.