OTULIN couples WNT signaling to resistance in triple-negative breast cancer

Wei Wang; Zhao-Hui Wu

doi:10.1080/23723556.2020.1825904

OTULIN couples WNT signaling to resistance in triple-negative breast cancer

Mol Cell Oncol. 2020 Oct 15;7(6):1825904. doi: 10.1080/23723556.2020.1825904. eCollection 2020.

Authors

Wei Wang^{1

2

3}, Zhao-Hui Wu^{1

2

3}

Affiliations

¹ Department of Radiation Oncology, University of Tennessee Health Science Center, Memphis, TN, USA.
² Department of Pathology and Laboratory Medicine, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.
³ Center for Cancer Research, University of Tennessee Health Science Center, Memphis, TN, USA.

Abstract

Oncogenic Wnt/β-catenin activation promotes cancer development and drug resistance to cancer treatments. We recently revealed an underlying mechanism linking linear ubiquitination with Wnt/β-catenin activation upon genotoxic treatments. We showed that ABL1 (ABL proto-oncogene 1)-dependent phosphorylation of OTULIN (OTU deubiquitinase with linear linkage specificity) upon DNA damage drives β-catenin activation which promotes drug resistance in triple-negative breast cancer.

Keywords: DNA damage; OTULIN; drug resistance; linear ubiquitination; β-catenin.