Multi-Responsive Silk Fibroin-Based Nanoparticles for Drug Delivery

Ya Ma; Brandon S B Canup; Xiaoling Tong; Fangyin Dai; Bo Xiao

doi:10.3389/fchem.2020.585077

Multi-Responsive Silk Fibroin-Based Nanoparticles for Drug Delivery

Front Chem. 2020 Nov 3:8:585077. doi: 10.3389/fchem.2020.585077. eCollection 2020.

Authors

Ya Ma^{1

2}, Brandon S B Canup³, Xiaoling Tong¹, Fangyin Dai¹, Bo Xiao¹

Affiliations

¹ State Key Laboratory of Silkworm Genome Biology, Key Laboratory of Sericultural Biology and Genetic Breeding, Ministry of Agriculture and Rural Affairs, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing, China.
² Chongqing Key Laboratory of Soft-Matter Material Chemistry and Function Manufacturing, School of Materials and Energy, Southwest University, Chongqing, China.
³ Department of Chemistry, Georgia State University, Atlanta, GA, United States.

Abstract

Silk fibroin has the merits of biocompatibility, biodegradability, ease of processing, and feasibility of modification, which present it as a promising drug delivery material. This review focuses on the structures of silk fibroin, the controlled transformation of secondary structures, and the formation mechanism of silk fibroin-based nanoparticles (SFNPs). We also discuss the intrinsic multi-responsive, surface functionalization, and transgenic modification of SFNPs for drug delivery.

Keywords: drug delivery; multi-responsibility; nanoparticle; silk fibroin; β-sheet.

Publication types

Review