Multi-Cellular Functions of MG53 in Muscle Calcium Signaling and Regeneration

Dathe Z Benissan-Messan; Hua Zhu; Weina Zhong; Tao Tan; Jianjie Ma; Peter H U Lee

doi:10.3389/fphys.2020.583393

Multi-Cellular Functions of MG53 in Muscle Calcium Signaling and Regeneration

Front Physiol. 2020 Nov 6:11:583393. doi: 10.3389/fphys.2020.583393. eCollection 2020.

Authors

Dathe Z Benissan-Messan¹, Hua Zhu¹, Weina Zhong¹, Tao Tan¹, Jianjie Ma¹, Peter H U Lee^{1

2

3}

Affiliations

¹ Department of Surgery, The Ohio State University, Columbus, OH, United States.
² Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, United States.
³ Department of Cardiothoracic Surgery, Southcoast Health, Fall River, MA, United States.

Abstract

Since its identification in 2009, multiple studies have indicated the importance of MG53 in muscle physiology. The protein is produced in striated muscles but has physiologic implications reaching beyond the confines of striated muscles. Roles in muscle regeneration, calcium homeostasis, excitation-contraction coupling, myogenesis, and the mitochondria highlight the protein's wide-reaching impact. Numerous therapeutic applications could potentially emerge from these physiologic roles. This review summarizes the current literature regarding the role of MG53 in the skeletal muscle. Therapeutic applications are discussed.

Keywords: TRIM72; calcium homeostasis; insulin resistance; metabolic syndrome; mitochondria; myogenesis; plasma membrane repair; skeletal muscle regeneration.

Publication types

Review

Abstract

Publication types

Grants and funding