Dynamic Glucose-Enhanced MR Imaging

Abstract

Conventional medical imaging techniques use contrast agents that are chemically labeled, for example, iodine in the case of computed tomography, radioisotopes in the case of PET, or gadolinium in the case of MR imaging to create or enhance signal contrast and to visualize tissue compartments and features. Dynamic glucose-enhanced MR imaging represents a novel technique that uses natural, unlabeled d-glucose as a nontoxic biodegradable contrast agent in chemical exchange-sensitive MR imaging approaches.

Keywords: Chemical exchange saturation transfer (CEST); Chemical exchange-sensitive spin-lock (CESL); GlucoCESL; GlucoCEST; Glucose-enhanced MR imaging; MR biomarkers.