Cerebrospinal fluid xanthochromia after pegasparaginase hepatotoxicity in B-cell acute lymphoblastic leukemia

Riccardo Moia; Mariangela Greco; Paola Boggione; Maura Nicolosi; Riccardo Bruna; Andrea Patriarca; Gianluca Gaidano; Monia Lunghi

doi:10.1002/ccr3.3114

Cerebrospinal fluid xanthochromia after pegasparaginase hepatotoxicity in B-cell acute lymphoblastic leukemia

Clin Case Rep. 2020 Jul 16;8(11):2293-2294. doi: 10.1002/ccr3.3114. eCollection 2020 Nov.

Authors

Riccardo Moia¹, Mariangela Greco¹, Paola Boggione¹, Maura Nicolosi¹, Riccardo Bruna¹, Andrea Patriarca¹, Gianluca Gaidano¹, Monia Lunghi¹

Affiliation

¹ Division of Hematology Department of Translational Medicine Università del Piemonte Orientale Novara Italy.

Abstract

Patients with B-lineage acute lymphoblastic leukemia treated with pegasparaginase-containing regimens can develop hepatotoxicity related to it. The systemic hyperbilirubinemia due to hepatotoxicity can lead to the development of CSF xanthochromia.

Keywords: ALL; CSF xanthochromia; hepatotoxicity; pegasparaginase.