Altered Biodistribution of 68Ga-DOTATOC

Clin Nucl Med. 2021 Feb 1;46(2):164-165. doi: 10.1097/RLU.0000000000003439.

Abstract

68Ga-DOTATOC PET/CT of a patient with metastatic neuroendocrine tumor reveals an abnormal biodistribution of the tracer with a vascular binding and a very low fixation on the known lesions despite the temporary discontinuation of "cold" somatostatin analogs. A possible interaction with a high intake of turmeric may be suspected by inhibition of hepatic uptake process.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neuroendocrine Tumors / diagnostic imaging
  • Neuroendocrine Tumors / metabolism
  • Octreotide / analogs & derivatives*
  • Octreotide / pharmacokinetics
  • Organometallic Compounds / pharmacokinetics*
  • Positron Emission Tomography Computed Tomography
  • Tissue Distribution

Substances

  • Ga(III)-DOTATOC
  • Organometallic Compounds
  • Octreotide