Decoding (patho-)physiology of the lung by advanced in vitro models for developing novel anti-infectives therapies

Carlos Victor Montefusco-Pereira; Cristiane de Souza Carvalho-Wodarz; Johanna Seeger; Charlotte Kloft; Robin Michelet; Claus-Michael Lehr

doi:10.1016/j.drudis.2020.10.016

Decoding (patho-)physiology of the lung by advanced in vitro models for developing novel anti-infectives therapies

Drug Discov Today. 2021 Jan;26(1):148-163. doi: 10.1016/j.drudis.2020.10.016. Epub 2020 Nov 21.

Authors

Carlos Victor Montefusco-Pereira¹, Cristiane de Souza Carvalho-Wodarz², Johanna Seeger³, Charlotte Kloft³, Robin Michelet³, Claus-Michael Lehr⁴

Affiliations

¹ Department of Pharmacy, Saarland University, Saarbruecken, Germany; Department of Clinical Pharmacy and Biochemistry, Institute of Pharmacy, Freie Universitaet Berlin, Germany.
² Department of Drug Delivery, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Saarbruecken, Germany. Electronic address: cristiane.carvalho@helmholtz-hips.de.
³ Department of Clinical Pharmacy and Biochemistry, Institute of Pharmacy, Freie Universitaet Berlin, Germany.
⁴ Department of Drug Delivery, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Saarbruecken, Germany; Department of Pharmacy, Saarland University, Saarbruecken, Germany.

PMID: 33232842
DOI: 10.1016/j.drudis.2020.10.016

Abstract

Advanced lung cell culture models provide physiologically-relevant and complex data for mathematical models to exploit host-pathogen responses during anti-infective drug testing.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Anti-Infective Agents / pharmacology*
Drug Discovery / methods*
Host-Pathogen Interactions / drug effects*
Humans
Lung Neoplasms* / immunology
Lung Neoplasms* / pathology
Lung Neoplasms* / physiopathology
Models, Biological
Models, Theoretical
Tumor Cells, Cultured

Substances

Anti-Infective Agents