Xyloglucan-based hybrid nanocomposite with potential for biomedical applications

Aiêrta Cristina Carrá da Silva; Raimundo Rafael de Almeida; Alexandre Carreira da Cruz Sousa; Fabián Nicolás Araneda Martínez; Juliano Casagrande Denardin; Selene Maia de Morais; Nágila Maria Pontes Silva Ricardo

doi:10.1016/j.ijbiomac.2020.11.128

Xyloglucan-based hybrid nanocomposite with potential for biomedical applications

Int J Biol Macromol. 2021 Jan 31:168:722-732. doi: 10.1016/j.ijbiomac.2020.11.128. Epub 2020 Nov 21.

Authors

Aiêrta Cristina Carrá da Silva¹, Raimundo Rafael de Almeida², Alexandre Carreira da Cruz Sousa³, Fabián Nicolás Araneda Martínez⁴, Juliano Casagrande Denardin⁴, Selene Maia de Morais⁵, Nágila Maria Pontes Silva Ricardo⁶

Affiliations

¹ Laboratory of Polymers and Materials Innovation, Department of Organic and Inorganic Chemistry, Sciences Center, Federal University of Ceará, Campus of Pici, Zip Code 60440-760 Fortaleza, CE, Brazil.
² Federal Institute of Education, Science and Technology of Ceará, Campus Camocim, Camocim, CE Zip Code 62400-000, Brazil.
³ Laboratory of Polymers and Materials Innovation, Department of Organic and Inorganic Chemistry, Sciences Center, Federal University of Ceará, Campus of Pici, Zip Code 60440-760 Fortaleza, CE, Brazil; Federal Institute of Education, Science and Technology of Ceará, Campus Quixadá, Quixadá, CE, Zip Code 63902-580, Brazil.
⁴ Department of Physics, University of Santiago and Cedenna, USACH-CEDENNA, Santiago Zip Code 9170124, Chile.
⁵ Laboratory of Natural Products, Science and Technology Center, Ceará State University, Campus of Itaperi, Zip Code 60714-903 Fortaleza, CE, Brazil.
⁶ Laboratory of Polymers and Materials Innovation, Department of Organic and Inorganic Chemistry, Sciences Center, Federal University of Ceará, Campus of Pici, Zip Code 60440-760 Fortaleza, CE, Brazil. Electronic address: naricard@ufc.br.

PMID: 33232700
DOI: 10.1016/j.ijbiomac.2020.11.128

Abstract

Natural polymer-based hybrid nanocomposites have been proposed as one of the most promising tools for biomedical applications, including disease treatment and diagnosis procedures. Xyloglucan nanocapsules can simultaneously load magnetic iron oxide nanoparticles and bioactive for a specific tissue, reducing the processes of degradation and metabolic inactivation of molecules with biological activity. In this work, magnetic nanocapsules of xyloglucan loaded with hydrophilic sulfated quercetin (MNXQ_SO₃) were successfully synthesized by inverse miniemulsion process through interfacial polymerization. The polymeric shell formation of nanocapsules was evidenced by Fourier Transform Infrared spectroscopy and Transmission Electron Microscopy. The ferrofluid (Fe₃O₄@PAAS) incorporated into the xyloglucan nanocapsules was synthesized by hydrothermal method, using polyacrylic acid sodium salt as coating. Dynamic Light Scattering technique confirmed the nanomeric dimensions (202.3 nm) and the good colloidal stability (-40.2 mV) of MNXQ_SO₃. The saturation magnetization analyses pointed out the superparamagnetic behavior of Fe₃O₄@PAAS (48 emu/g) and MNXQ_SO₃ (4.2 emu/g). MNXQ_SO₃ was able to modify the release profile of sulfated quercetin (67%) when compared to the free bioactive (100%), exhibiting a release profile compatible with the zero-order kinetic model. The results showed that the development of MNXQ_SO₃ presents a new perspective for biomedical applications, including studies of targeted drug delivery.

Keywords: Biomedical applications; Magnetic nanocapsules of xyloglucan; Targeted drug delivery.

MeSH terms

Drug Delivery Systems
Dynamic Light Scattering
Glucans / chemistry*
Kinetics
Magnetite Nanoparticles
Microscopy, Electron, Transmission
Particle Size
Quercetin / chemical synthesis*
Quercetin / chemistry
Quercetin / pharmacology
Spectroscopy, Fourier Transform Infrared
Sulfides / chemistry*
Xylans / chemistry*

Substances

Glucans
Magnetite Nanoparticles
Sulfides
Xylans
xyloglucan
Quercetin