Large bowel obstruction from advanced prostate cancer in a 41-year-old: the role of genetic testing

J B Jonosky; N De Villiers; R Wadee; F Chinegwundoh; A Adam

Large bowel obstruction from advanced prostate cancer in a 41-year-old: the role of genetic testing

S Afr J Surg. 2020 Sep;58(3):163.

Authors

J B Jonosky¹, N De Villiers², R Wadee³, F Chinegwundoh⁴, A Adam¹

Affiliations

¹ Department of Urology, Helen Joseph Hospital, South Africa, Department of Paediatric Urology, Rahima Moosa Mother & Child (Coronation) Hospital, South Africa and Division of Urology, Department of Surgery, Faculty of Health Sciences, University of the Witwatersrand, South Africa.
² AMPATH Genetics, South Africa.
³ Division of Anatomical Pathology, University of the Witwatersrand, South Africa and National Health Laboratory Services (NHLS), South Africa.
⁴ Department of Urology, Barts Health NHS Trust, United Kingdom.

PMID: 33231013

Abstract

We report a rare presentation of an advanced prostate cancer (Gleason 10) in a 41-year-old man with complete large bowel obstruction relieved by loop colostomy. His young age prompted a search for a cause and genetic testing confirmed chromosome 10 PTEN deletion. His immediate family members were screened and counselled appropriately. This case outlines the role of genetic testing in young males with prostate cancer.

Publication types

Case Reports

MeSH terms

Adult
Colostomy
Genetic Testing
Humans
Intestinal Obstruction / etiology*
Intestinal Obstruction / surgery
Male
PTEN Phosphohydrolase / genetics*
Prostatic Neoplasms / diagnosis*
Prostatic Neoplasms / genetics*
Prostatic Neoplasms / surgery

Substances

PTEN Phosphohydrolase
PTEN protein, human