Comparison of hydrolases, peroxidase and protease inhibitors in bronchoalveolar fluid from Macacus cynomolgus and human controls

M H Hannothiaux; A Scharfman; J J Lafitte; L Cornu; H Daniel; P Roussel

doi:10.1016/0305-0491(87)90359-2

Comparison of hydrolases, peroxidase and protease inhibitors in bronchoalveolar fluid from Macacus cynomolgus and human controls

Comp Biochem Physiol B. 1987;88(2):655-60. doi: 10.1016/0305-0491(87)90359-2.

Authors

M H Hannothiaux¹, A Scharfman, J J Lafitte, L Cornu, H Daniel, P Roussel

Affiliation

¹ Unité des Protéines INSERM No. 16, Lille, France.

PMID: 3322659
DOI: 10.1016/0305-0491(87)90359-2

Abstract

1. Serial bronchoalveolar lavages were performed on a subhuman primate (Macacus cynomolgus) in order to give an experimental model for silicosis. 2. We have measured glycosidases, proteases, peroxidase and antiproteases of the BAL fluids from seven normal monkeys. 3. The results obtained were similar to those found in human control BAL fluids. 4. For monkeys, the repetition of the bronchoalveolar procedure does not seem to have an important influence on the values obtained. 5. The present results will now permit sequential follow up studies during the course of experimental silicosis.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Bronchoalveolar Lavage Fluid / analysis
Bronchoalveolar Lavage Fluid / enzymology*
Electrophoresis, Polyacrylamide Gel
Female
Humans
Hydrolases / metabolism*
Immunoelectrophoresis, Two-Dimensional
Macaca fascicularis
Peptide Hydrolases / metabolism*
Peroxidases / metabolism*
Protease Inhibitors / analysis*

Substances

Protease Inhibitors
Peroxidases
Hydrolases
Peptide Hydrolases