Hemodynamic study in 3D printed stenotic coronary artery models: experimental validation and transient simulation

Comput Methods Biomech Biomed Engin. 2021 May;24(6):623-636. doi: 10.1080/10255842.2020.1842377. Epub 2020 Nov 23.

Abstract

Atherosclerosis is a progressive disease that can significantly reduce blood supply to vital organs, being one of the main causes of death worldwide. In this work, a numerical and experimental study in 3D printed stenotic coronary arteries, considering both steady and pulsatile blood flow conditions, is presented. The results revealed that a degree of stenosis superior to 50% creates disturbed flows downstream of the contraction, with an accented increase in the wall shear stress measurements at the stenosis throat. Finally, the multiphase mixture was investigated and compared with a single-phase modelling, and only slight differences were observed right after the stenosis throat.

Keywords: Atherosclerosis; CFD; blood flow; multiphase flow; turbulence modeling; validation.

Publication types

  • Validation Study

MeSH terms

  • Blood Flow Velocity / physiology
  • Computer Simulation*
  • Coronary Stenosis / physiopathology*
  • Coronary Vessels / physiopathology*
  • Hemodynamics / physiology*
  • Humans
  • Models, Cardiovascular*
  • Numerical Analysis, Computer-Assisted
  • Printing, Three-Dimensional*