1H,13C and 15N chemical shift assignments of the SUD domains of SARS-CoV-2 non-structural protein 3c: "the N-terminal domain-SUD-N"

Biomol NMR Assign. 2021 Apr;15(1):85-89. doi: 10.1007/s12104-020-09987-y. Epub 2020 Nov 23.

Abstract

Among the proteins encoded by the SARS-CoV-2 RNA, nsP3 (non-structural Protein3) is the largest multi-domain protein. Its role is multifaceted and important for the viral life cycle. Nonetheless, regarding the specific role of each domain there are many aspects of their function that have to be investigated. SARS Unique Domains (SUDs), constitute the nsP3c region of the nsP3, and were observed for the first time in SARS-CoV. Two of them, namely SUD-N (the first SUD) and the SUD-M (sequential to SUD-N), exhibit structural homology with nsP3b ("X" or macro domain); indeed all of them are folded in a three-layer α/β/α sandwich. On the contrary, they do not exhibit functional similarities, like ADP-ribose binding properties and ADP-ribose hydrolase activity. There are reports that suggest that these two SUDs may exhibit a binding selectivity towards G-oligonucleotides, a feature which may contribute to the characterization of their role in the formation of the replication/transcription viral complex (RTC) and of the interaction of various viral "components" with the host cell. While the structures of these domains of SARS-CoV-2 have not been determined yet, SUDs interaction with oligonucleotides and/or RNA molecules may provide a platform for drug discovery. Here, we report the almost complete NMR backbone and side-chain resonance assignment (1H,13C,15N) of SARS-CoV-2 SUD-N protein, and the NMR chemical shift-based prediction of the secondary structure elements. These data may be exploited for its 3D structure determination and the screening of chemical compounds libraries, which may alter SUD-N function.

Keywords: Covid19-NMR; Non-structural protein; Protein druggability; SARS unique domain (SUD); SARS-CoV-2; Solution NMR-spectroscopy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carbon Isotopes
  • Coronavirus Papain-Like Proteases / chemistry*
  • Drug Design
  • Hydrogen
  • Magnetic Resonance Spectroscopy*
  • Nitrogen Isotopes
  • Oligonucleotides / chemistry
  • Protein Domains
  • Protein Structure, Secondary
  • SARS-CoV-2 / chemistry*
  • Virus Replication

Substances

  • Carbon Isotopes
  • Nitrogen Isotopes
  • Nitrogen-15
  • Oligonucleotides
  • Hydrogen
  • Coronavirus Papain-Like Proteases
  • papain-like protease, SARS-CoV-2
  • Carbon-13