Polymorphisms in the interleukin genes and chronic periodontitis: A field synopsis and revaluation by Bayesian approaches

Cytokine. 2021 Feb:138:155361. doi: 10.1016/j.cyto.2020.155361. Epub 2020 Nov 19.

Abstract

Periodontitis is a high prevalent disease into the clinical dentistry. Genetic variations in interleukins (IL) genes were associated with chronic periodontitis (CP) and were focus of several meta-analyses. This study aimed to assess the noteworthiness in the meta-analyses by means of a Bayesian approach to determinate possible false report associations. A systematic search was performed for meta-analyses with associations between gene polymorphisms in interleukins and CP. The calculations for the False-Positive Rate Probability (FPRP) and the Bayesian False Discovery Probability (BFDP) were performed to assess the noteworthiness with a statistical power of 1.2 and 1.5 of Odds Ratio at a prior probability of 10-3 and 10-6. As results, eight meta-analyses approaching the IL1A/rs1800587, IL1B/rs1143634, IL1RN/rs2234663, IL4/rs2243250, IL6/rs1800795/rs1800796, IL17A/rs2275913 and IL18/rs1946518/rs187238 polymorphisms have been identified. Twenty-two from 270 calculations (8.15%) were noteworthy. Herein, we have identified the IL1A and IL1B polymorphisms as noteworthy biomarkers for CP susceptibility.

Keywords: Alleles; Genetic variations; Odds ratio; Periodontal diseases; Risk factors.

Publication types

  • Systematic Review

MeSH terms

  • Bayes Theorem
  • Biomarkers / metabolism
  • Chronic Periodontitis / genetics*
  • False Positive Reactions
  • Genetic Predisposition to Disease*
  • Humans
  • Inflammation Mediators
  • Interleukin-1beta / genetics*
  • Meta-Analysis as Topic
  • Odds Ratio
  • Polymorphism, Single Nucleotide*
  • Probability

Substances

  • Biomarkers
  • IL1B protein, human
  • Inflammation Mediators
  • Interleukin-1beta