Advances and Future Directions of Neuromodulation in Neurologic Disorders

Abstract

"Deep brain stimulation is a safe and effective therapy for the management of a variety of neurologic conditions with Food and Drug Administration or humanitarian exception approval for Parkinson disease, dystonia, tremor, and obsessive-compulsive disorder. Advances in neurophysiology, neuroimaging, and technology have driven increasing interest in the potential benefits of neurostimulation in other neuropsychiatric conditions including dementia, depression, pain, Tourette syndrome, and epilepsy, among others. New anatomic or combined targets are being investigated in these conditions to improve symptoms refractory to medications or standard stimulation."

Keywords: Chorea; Chronic pain; Deep brain stimulation; Dystonia; Epilepsy; Essential tremor; Parkinson disease; Tourette syndrome.